R
Randall K. Mann
Researcher at Stanford University
Publications - 12
Citations - 2941
Randall K. Mann is an academic researcher from Stanford University. The author has contributed to research in topics: Hedgehog & Hedgehog signaling pathway. The author has an hindex of 11, co-authored 12 publications receiving 2781 citations. Previous affiliations of Randall K. Mann include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Jussi Taipale,James K. Chen,Michael K. Cooper,Baolin Wang,Randall K. Mann,Ljiljana Milenkovic,Matthew P. Scott,Philip A. Beachy +7 more
TL;DR: It is shown that the plant-derived teratogen cyclopamine, which inhibits the Hh response, is a potential ‘mechanism-based’ therapeutic agent for treatment of these tumours.
Journal ArticleDOI
Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal
Zeina Chamoun,Randall K. Mann,Denise Nellen,Doris P. von Kessler,Manolo Bellotto,Philip A. Beachy,Konrad Basler +6 more
TL;DR: A segment polarity gene in Drosophila melanogaster, skinny hedgehog(ski), is identified, and it is shown that its product is required in Hh-expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues.
Journal ArticleDOI
Novel Lipid Modifications of Secreted Protein Signals
Randall K. Mann,Philip A. Beachy +1 more
TL;DR: The cellular mechanisms that have evolved to handle lipidated Hh proteins in the spatial deployment of the signal in developing tissues are discussed and the more recent findings that implicate palmitate modification as an important feature of Wnt signaling proteins are discussed.
Journal ArticleDOI
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.
Lawrence G. Lum,Chi Zhang,Sekyung Oh,Randall K. Mann,Doris P. von Kessler,Jussi Taipale,Frances Weis-Garcia,Ruoyu Gong,Baolin Wang,Philip A. Beachy +9 more
TL;DR: Evidence is presented that Smo associates directly with a Ci-containing complex that is scaffolded and stabilized by the atypical kinesin, Costal-2 (Cos2), which constitutively suppresses pathway activity, but Hh signaling reverses its regulatory effect to promote Ci-mediated transcription.
Journal ArticleDOI
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form
Adrian Creanga,Thomas D. Glenn,Randall K. Mann,Adam M. Saunders,William S. Talbot,Philip A. Beachy +5 more
TL;DR: The structural determinants of Scube2 required for its activity in cultured cell assays match those required for rescue of you mutant zebrafish embryos, and it is concluded that the role of Scubes/You proteins in Hh signaling in vivo is to facilitate the release and mobilization of Hh proteins for distant action.