Randi Chen

TL;DR: Long-lived men presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls, several of these aging phenotypes were associated with FOXO3A genotype.

TL;DR: Data cast doubt on the scientific justification for lowering cholesterol to very low concentrations (<4.65 mmol/L) in elderly people.

TL;DR: In a seven-year follow-up of 2,340 men aged 71–93 in the Honolulu Heart Program, the age-adjusted CHD incidence rates were significantly lower in men with high versus low HDL-C levels, and whether a CETP mutation offers additional protection against CHD warrants further investigation.

TL;DR: High grip strength and avoidance of overweight, hyperglycemia, hypertension, smoking, and excessive alcohol consumption were associated with both overall and exceptional survival, and lack of a marital partner was associated with mortality before age 85 years.

TL;DR: These findings confirm expected relationships between impaired glucose tolerance and stroke-related dementia but do not support an association of disordered glucose metabolism with AD.