Kamal Masaki

TL;DR: Estrogen therapy alone did not reduce dementia or MCI incidence and increased the risk for both end points combined and use of hormone therapy to prevent dementia or cognitive decline in women 65 years of age or older is not recommended.

TL;DR: Elevated levels of blood pressure in middle age can increase the risk for late age dementia in men never treated with anti-hypertensive medication, and these results were consistent for Alzheimer's disease and vascular dementia.

TL;DR: This work defines frailty using simple indicators and investigates the predictive validity of this frailty classification for death, hospitalization, hip fracture, and activity of daily living disability.

TL;DR: Midlife SBP is a significant predictor of reduced cognitive function in later life and early control of SBP levels may reduce the risk for cognitive impairment in old age.

TL;DR: Long-lived men presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls, several of these aging phenotypes were associated with FOXO3A genotype.