R
Randolph R.J. Arroo
Researcher at De Montfort University
Publications - 88
Citations - 1925
Randolph R.J. Arroo is an academic researcher from De Montfort University. The author has contributed to research in topics: Flavones & Kaempferol. The author has an hindex of 23, co-authored 83 publications receiving 1549 citations. Previous affiliations of Randolph R.J. Arroo include Radboud University Nijmegen.
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Journal ArticleDOI
Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism
Vasilis P. Androutsopoulos,Randolph R.J. Arroo,John F. Hall,Somchaiya Surichan,Gerry A. Potter +4 more
TL;DR: The flavone eupatorin is selectively activated in breast cancer cells, but not in normal breast cells, due to CYP1 family metabolism, which provides a basis for selectivity which is desired against breast tumour cells.
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Pinoresinol–lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax (Linum usitatissimum) seeds
Christophe Hano,I. Martin,Ophélie Fliniaux,Baptiste Legrand,Laurent Gutierrez,Randolph R.J. Arroo,François Mesnard,Frédéric Lamblin,Eric Lainé +8 more
TL;DR: Three-way approach demonstrated that the LuPLR gene is expressed in the seed coat of flax seeds, and that the synthesis of PLR enzyme occurs where flax main lignan is found stored in mature seeds, confirming its involvement in SDG synthesis.
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Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol.
Keti Zeka,Ketan C. Ruparelia,Maria Adelaide Continenza,Dimitrios Stagos,Francesco Vegliò,Randolph R.J. Arroo +5 more
TL;DR: Petals of C. sativus L. have commercial potential as a source for kaempferol and crocetin glycosides, natural compounds with antioxidant activity that are considered to be the active ingredients in saffron-based herbal medicine.
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Biosynthesis of podophyllotoxin in Linum album cell cultures
Veronique Seidel,Jorg Windhövel,Graham Eaton,A. Wilhelm Alfermann,Randolph R.J. Arroo,Manuel Medarde,Maike Petersen,Jack G. Woolley +7 more
TL;DR: Observations suggest that in L. album both ferulic acid and methylenedioxy-substituted cinnamic acid can be incorporated into lignans, and it appears that the hydroxylation of DOP is a rate-limiting point in the pathway leading to PTOX.
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CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.
Vasilis P. Androutsopoulos,Vasilis P. Androutsopoulos,Ketan C. Ruparelia,Randolph R.J. Arroo,Aristidis Tsatsakis,Demetrios A. Spandidos +5 more
TL;DR: The data suggests that CYP1 family enzymes enhance the antiproliferative activity of dietary flavonoids in breast cancer cells, through bioconversion to more active products.