R
Randy Hoffman
Researcher at Invitrogen
Publications - 6
Citations - 927
Randy Hoffman is an academic researcher from Invitrogen. The author has contributed to research in topics: Signal transduction & Protein kinase B. The author has an hindex of 6, co-authored 6 publications receiving 872 citations. Previous affiliations of Randy Hoffman include Life Technologies.
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Journal ArticleDOI
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Beth Apsel,Jimmy A. Blair,Beatriz González,Beatriz González,Tamim Nazif,Morri E. Feldman,Brian Aizenstein,Randy Hoffman,Roger L. Williams,Kevan M. Shokat,Kevan M. Shokat,Zachary A. Knight,Zachary A. Knight +12 more
TL;DR: It is shown that one compound, PP121, blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and PI3-Ks, and demonstrates the feasibility of accessing a chemical space that intersects two families ofoncogenes.
Journal ArticleDOI
Inhibitor Hijacking of Akt Activation
Tatsuya Okuzumi,Dorothea Fiedler,Chao Zhang,Daniel C. Gray,Brian Aizenstein,Randy Hoffman,Kevan M. Shokat,Kevan M. Shokat +7 more
TL;DR: It is concluded that ATP-competitive Akt inhibitors impart regulatory phosphorylation of their target kinase Akt providing new insights into both natural regulation of Akt activation andAkt inhibitors entering the clinic.
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Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs
Olusegun Williams,Benjamin T. Houseman,Eric J. Kunkel,Brian Aizenstein,Randy Hoffman,Zachary A. Knight,Kevan M. Shokat +6 more
TL;DR: It is found selective inhibition of only PI3Kdelta is weakly anti-inflammatory, but PI3kdelta/gamma inhibitors show superior inflammatory marker suppression through suppression of lipopolysaccharide-induced TNFalpha production and T cell activation.
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Overcoming compound interference in fluorescence polarization-based kinase assays using far-red tracers.
Kevin L. Vedvik,Hildegard C. Eliason,Randy Hoffman,Jasmin R. Gibson,Kevin R. Kupcho,Richard Somberg,Kurt W. Vogel +6 more
TL;DR: The PanVera PolarScreen far- red fluorescence polarization assay format is described, which mitigates assay interference from autofluorescent compounds or scattered light through the use of a far-red tracer.
Journal ArticleDOI
A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors.
Jinhua Chen,Ziming Zhang,John L. Stebbins,Xiyun Zhang,Randy Hoffman,Ambika Moore,Maurizio Pellecchia +6 more
TL;DR: It is demonstrated that a pharmacophore-based search guided by experimental binding data of weakly in- teracting fragments can be rapidly and efficiently used to identify (or synthesize) high-affinity, selective ligands.