Raphael H. Rastetter

TL;DR: It is shown that the adult stem cell marker Lgr5 is expressed in the cortical region of the fetal ovary and this expression is mutually exclusive to FOXL2, and a third somatic cell population can be identified, marked by the expression of NR2F2, which is expresses in LGR5- and FoxL2 double-negative ovarian somatic cells.

TL;DR: This chapter provides an introduction about the current knowledge of the main classes of non-coding RNAs, what is know about their biogenesis and mechanism of function and makes amazing progress in elucidating their expression, biogenesis, mechanisms and mode of action.

TL;DR: It is demonstrated that XX fetal gonads contain GATA4 expressing supporting cells that either enter mitotic arrest, or remain proliferative, and a balance between supporting cell self-renewal and differentiation is maintained in the developing ovary by relative WNT/β-catenin and p27/FOXL2 activities.

TL;DR: The role of non-coding RNAs (ncRNAs) in male sex determination and differentiation has been extensively studied as discussed by the authors, and it has been shown that they play a role in almost all developmental and physiological pathways.

TL;DR: In recent years, extensive data have shown that different classes of non-coding RNAs play a role in almost all developmental and physiological pathways, but the authors are still far from having a complete picture.