R
Raquel Largo
Researcher at Autonomous University of Madrid
Publications - 136
Citations - 5407
Raquel Largo is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Osteoarthritis & Cartilage. The author has an hindex of 38, co-authored 121 publications receiving 4662 citations. Previous affiliations of Raquel Largo include Complutense University of Madrid & Carlos III Health Institute.
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Journal ArticleDOI
Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes
Raquel Largo,M A Alvarez-Soria,I Díez-Ortego,Emilio Calvo,Olga Sánchez-Pernaute,Jesús Egido,Gabriel Herrero-Beaumont +6 more
TL;DR: The role of GS as a symptom- and structure-modifying drug in the treatment of OA is supported, as it inhibits the synthesis of proinflammatory mediators in HOC stimulated with IL-1β through a NFκB-dependent mechanism.
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Osteoarthritis associated with estrogen deficiency
TL;DR: A better understanding of how estrogen acts on joints and other tissues in OA will aid the development of specific and safe estrogen ligands as novel therapeutic agents targeting the OA joint as a whole organ.
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Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure.
Bernardo Rodriguez-Iturbe,Héctor Pons,Yasmir Quiroz,Katherine L. Gordon,Jaimar Rincon,Maribel Chávez,Gustavo Parra,Jaime Herrera-Acosta,Dulcenombre Gómez-Garre,Raquel Largo,Jesús Egido,Richard J. Johnson +11 more
TL;DR: SSHTN resulting from Ang II infusion is associated with infiltration and activation of immune cells that produce Ang II and mycophenolate mofetil treatment reduces these features and prevents the development of SSHTN.
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Subchondral bone as a key target for osteoarthritis treatment.
TL;DR: This review focuses on the role of SB in OA pathogenesis, describing relevant underlying mechanisms involved in the process and examining the potential activity as disease-modifying anti-osteoarthritic drugs (DMOADs) of certain SB-targeting agents currently under study.
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Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
M. Bellido,L. Lugo,Jorge A. Roman-Blas,Santos Castañeda,José R. Caeiro,Sonia Dapía,Emilio Calvo,Raquel Largo,Gabriel Herrero-Beaumont +8 more
TL;DR: The results suggest that an increased subchondral bone resorption may account for the exacerbation of cartilage damage when early OA and OP coexist simultaneously in same individuals.