J
Jorge A. Roman-Blas
Researcher at Autonomous University of Madrid
Publications - 44
Citations - 2892
Jorge A. Roman-Blas is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Osteoarthritis & Osteoporosis. The author has an hindex of 26, co-authored 44 publications receiving 2514 citations. Previous affiliations of Jorge A. Roman-Blas include Thomas Jefferson University.
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NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
TL;DR: Promising strategies such as improved antisense DNA therapy and RNA interference have been examined with encouraging results, but further research will be needed before NF-κB-aimed strategies become an effective therapy for joint diseases, such as OA and RA.
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Osteoarthritis associated with estrogen deficiency
TL;DR: A better understanding of how estrogen acts on joints and other tissues in OA will aid the development of specific and safe estrogen ligands as novel therapeutic agents targeting the OA joint as a whole organ.
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Subchondral bone as a key target for osteoarthritis treatment.
TL;DR: This review focuses on the role of SB in OA pathogenesis, describing relevant underlying mechanisms involved in the process and examining the potential activity as disease-modifying anti-osteoarthritic drugs (DMOADs) of certain SB-targeting agents currently under study.
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Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
M. Bellido,L. Lugo,Jorge A. Roman-Blas,Santos Castañeda,José R. Caeiro,Sonia Dapía,Emilio Calvo,Raquel Largo,Gabriel Herrero-Beaumont +8 more
TL;DR: The results suggest that an increased subchondral bone resorption may account for the exacerbation of cartilage damage when early OA and OP coexist simultaneously in same individuals.
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Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
TL;DR: The 3 proposed subsets of OA display distinct etiological, clinical, and therapeutic characteristics and should therefore no longer be considered to be "Primary OA."