Journal ArticleDOI
Subchondral bone as a key target for osteoarthritis treatment.
Reads0
Chats0
TLDR
This review focuses on the role of SB in OA pathogenesis, describing relevant underlying mechanisms involved in the process and examining the potential activity as disease-modifying anti-osteoarthritic drugs (DMOADs) of certain SB-targeting agents currently under study.About:
This article is published in Biochemical Pharmacology.The article was published on 2012-02-01. It has received 228 citations till now. The article focuses on the topics: Bone remodeling & Osteoarthritis.read more
Citations
More filters
Journal ArticleDOI
Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes
Guangyi Li,Guangyi Li,Ji-Min Yin,Junjie Gao,Tak Sum Cheng,Nathan J. Pavlos,Changqing Zhang,Ming H. Zheng +7 more
TL;DR: Basic features of the osteochondral junction, which comprises subchondral bone and articular cartilage, are summarized and a hypothetical model for the pathogenesis of OA is proposed.
Journal ArticleDOI
The NF-κB signalling pathway in osteoarthritis
TL;DR: The involvement of NF-κB in OA pathogenesis and how pharmacological inhibition of the NF-πB signalling pathway affects OA incidence and evolution are discussed.
Journal ArticleDOI
Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis
TL;DR: Current knowledge on the major signaling pathways that could control the cartilage-bone biochemical unit in joints and participate in intercellular communication between cartilage and subchondral bone during the process of OA are summarized.
Journal ArticleDOI
Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies.
TL;DR: The premise for the presence of crosstalk in bone-cartilage interface as well as the current knowledge of the major signalling pathways and molecular interactions that regulate OA progression are summarised.
Journal ArticleDOI
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Shouan Zhu,Jianxi Zhu,Jianxi Zhu,Gehua Zhen,Yihe Hu,Senbo An,Senbo An,Yusheng Li,Yusheng Li,Qin Zheng,Zhiyong Chen,Ya Yang,Mei Wan,Richard L. Skolasky,Yong Cao,Tianding Wu,Bo Gao,Mi Yang,Manman Gao,Julia S. Kuliwaba,Shuangfei Ni,Lei Wang,Chuanlong Wu,David M. Findlay,Holger K. Eltzschig,Hongwei Ouyang,Janet L. Crane,Feng Quan Zhou,Yun Guan,Xinzhong Dong,Xu Cao +30 more
TL;DR: Results suggest that intervention of the axonal guidance molecules (e.g., netrin-1) derived from aberrant subchondral bone remodeling may have therapeutic potential for OA pain.
References
More filters
Journal ArticleDOI
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
TL;DR: The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.
Journal ArticleDOI
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
William S. Simonet,David L. Lacey,Colin R. Dunstan,Michael J. Kelley,Ming-Shi Chang,R Lüthy,Hung Q. Nguyen,S Wooden,L Bennett,Tom Boone,Grant Shimamoto,Margaret L. DeRose,Robin Elliott,Anne Colombero,Hong-Lin Tan,Geraldine Trail,John K. Sullivan,E. Davy,N. Bucay,L Renshaw-Gegg,T.M Hughes,Dave Hill,W Pattison,Patricia Shehan Campbell,S Sander,Gwyneth Van,John E. Tarpley,P Derby,Richard Lee,William J. Boyle +29 more
TL;DR: Data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.
Journal ArticleDOI
Role of subchondral bone in the initiation and progression of cartilage damage.
Eric L. Radin,Robert M. Rose +1 more
TL;DR: In certain models of osteoarthrosis, alterations of the bony bed occur before the cartilage changes and suggest that this can occur in clinical conditions.
Journal ArticleDOI
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
TL;DR: This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis.
Journal ArticleDOI
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
Chen Zhao,Naoko Irie,Yasunari Takada,Kouji Shimoda,Takeshi Miyamoto,Toru Nishiwaki,Toshio Suda,Koichi Matsuo +7 more
TL;DR: It is demonstrated that ephrin-Eph bidirectional signaling links two major molecular mechanisms for cell differentiation--one in osteoclasts and the other in osteoblasts--thereby maintaining bone homeostasis.