R
Ratnadeep Basu
Researcher at University of Alberta
Publications - 54
Citations - 4087
Ratnadeep Basu is an academic researcher from University of Alberta. The author has contributed to research in topics: Angiotensin II & Heart failure. The author has an hindex of 32, co-authored 52 publications receiving 3425 citations. Previous affiliations of Ratnadeep Basu include Alberta Health Services.
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Journal ArticleDOI
Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction
Jiu-Chang Zhong,Ratnadeep Basu,Danny Guo,Fung L. Chow,Simon Byrns,Manfred Schuster,Hans Loibner,Xiuhua Wang,Josef M. Penninger,Zamaneh Kassiri,Gavin Y. Oudit +10 more
TL;DR: Elevated Ang II induced hypertension, myocardial hypertrophy, fibrosis, and diastolic dysfunction were exacerbated by ACE2 deficiency, whereas rhACE2 attenuated Ang II– and pressure-overload–induced adverse myocardia remodeling, suggesting ACE2 is an important negative regulator of Ang II-induced heart disease and suppresses adverse myCardial remodeling.
Journal ArticleDOI
Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy
Gavin Y. Oudit,George Liu,Jiu-Chang Zhong,Ratnadeep Basu,Fung L. Chow,Joyce Zhou,Hans Loibner,Evelyne Janzek,Manfred Schuster,Josef M. Penninger,Andrew M. Herzenberg,Zamaneh Kassiri,James W. Scholey +12 more
TL;DR: Treatment with hrACE2 attenuates diabetic kidney injury in the Akita mouse in association with a reduction in blood pressure and a decrease in NADPH oxidase activity, and in vitro studies show that the protective effect of hrace2 is due to reduction in ANG II and an increase in ANG 1–7 signaling.
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Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS
Vaibhav B. Patel,Nicola E. Clarke,Zuocheng Wang,Dong Fan,Nirmal Parajuli,Ratnadeep Basu,Brendan N. Putko,Zamaneh Kassiri,Anthony J. Turner,Gavin Y. Oudit +9 more
TL;DR: In conclusion, Ang II induces ACE2 shedding by promoting TACE activity as a positive feedback mechanism whereby Ang II facilitates the loss of its negative regulator, ACE2.
Journal ArticleDOI
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity
Vaibhav B. Patel,Jun Mori,Brent A. McLean,Ratnadeep Basu,Subhash K. Das,Tharmarajan Ramprasath,Nirmal Parajuli,Josef M. Penninger,Maria B. Grant,Gary D. Lopaschuk,Gavin Y. Oudit +10 more
TL;DR: In this article, the role of ACE2 in obesity-related cardiac dysfunction was investigated in mice fed a high-fat diet (HFD) or a control diet (WT) at 6 months of age.
Journal ArticleDOI
Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia-Reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues
Wang Wang,Shaun M. K. McKinnie,Vaibhav B. Patel,George Haddad,Zuocheng Wang,Pavel Zhabyeyev,Subhash K. Das,Ratnadeep Basu,Brent A. McLean,Vijay Kandalam,Josef M. Penninger,Zamaneh Kassiri,John C. Vederas,Allan G. Murray,Gavin Y. Oudit +14 more
TL;DR: APLN is a critical regulator of the myocardial response to infarction and ischemia and pharmacologically targeting this pathway is feasible and represents a new class of potential therapeutic agents.