Rawaf Alenazy

TL;DR: Novel chromanone and 2H-benzo[h]chromene derivatives were designed by means of integrated molecular design and structure-based pharmacophore modeling in an attempt to identify improved efflux pump inhibitors that target Escherichia coli AcrB.

TL;DR: Small molecule inhibitors that target drug efflux pumps especially the AcrAB-TolC multidrug efflux pump appear as a new promising and attractive approach that could increase the required accumulation of antimicrobials to eliminate bacteria as well as leading to reverse antibiotic resistance and prevent the development of resistance in clinically relevant bacterial pathogens.

TL;DR: Significantly, compound A5 possessed the most potent antibacterial synergizing activity in combination with levofloxacin by 4 times and 16 times at the concentration of 8 and 16 µg/mL, respectively, whilst A5 could effectively abolish Nile Red efflux at 100 μM.

TL;DR: In this paper , a review of different efflux pumps, their regulators, and inhibitors are summarized to target the antibiotic resistance pattern of Salmonella, and a special focus is made to elucidate the roles of salmonella efflux pump in virulence and biofilm formation.

TL;DR: In this article , essential oils (EOs) obtained by hydro-distillation from different parts of twigs, leaves, and fruits of Eucalyptus gunnii Hook were screened for their chemical composition, insecticidal, repellence, and antibacterial properties.