R
Raymond J. MacDonald
Researcher at University of Texas Southwestern Medical Center
Publications - 124
Citations - 31069
Raymond J. MacDonald is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Gene expression & Pancreas. The author has an hindex of 56, co-authored 121 publications receiving 30650 citations. Previous affiliations of Raymond J. MacDonald include University of Pennsylvania & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome
Nicola J. Craig,María B. Durán Alonso,Kim L. Hawker,Paul G. Shiels,Thora A. Glencorse,J.M Campbell,N.K. Bennett,Maurice Canham,Denise Donald,Mary T. Gardiner,D.P. Gilmore,Raymond J. MacDonald,Kirsty Maitland,Andrew S. McCallion,David Russell,Anthony P. Payne,R G Sutcliffe,R. Wayne Davies +17 more
TL;DR: Evidence is presented that this phenotype is due to a mutation in the rat protein kinase Cγ gene, which generates a premature stop codon, drastically reducing the level of synthesis of the catalytic domain of the brain-specific protein kinases Cγ protein.
Journal ArticleDOI
Rat pancreatic ribonuclease messenger RNA. The nucleotide sequence of the entire mRNA and the derived amino acid sequence of the pre-enzyme.
TL;DR: The mRNA sequence of rat pancreatic ribonuclease is cloned via recombinant DNA technology, and the entire nucleotide sequence of the mature message is determined, which encodes a secretory preRNase and contains long 5' and 3' noncoding regions relative to other pancreatic mRNAs.
Journal ArticleDOI
Expression of two kallikrein gene family members in the rat prostate.
TL;DR: Two kallikrein gene family members expressed in the prostate and submaxillary glands of rats are characterized, one of which encodes an enzyme closely related to tonin and the other encodes a novel kallIKrein-like enzyme that retains key amino acid residues responsible for the characteristic enzymatic cleavage specificity of kall Kikrein.
Journal ArticleDOI
Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.
David Meredith,Mark D. Borromeo,Tye G. Deering,Bradford Casey,Trisha K. Savage,Paul R. Mayer,Chinh Q. Hoang,Kuang-Chi Tung,Manonmani Kumar,Chengcheng Shen,Galvin H. Swift,Raymond J. MacDonald,Jane E. Johnson +12 more
TL;DR: Together, these findings indicate that lineage-specific chromatin landscapes likely constrain the DNA binding of Ptf1a, and they identify Fox and Sox gene families as part of this process.
Journal ArticleDOI
Tissue-specific expression of kallikrein family transgenes in mice and rats.
TL;DR: Analysis of the expression of several kallikrein/SV40 T-antigen fusion genes in transgenic mice and rats indicates that control elements that direct the particular nonsalivary gland expression pattern characteristic of each family member may be present within the proximal 5'-flanking region of each gene.