Rebecca Conrad

TL;DR: The ability of dimethylfumarate to activate nuclear factor (erythroid-derived 2)-related factor 2 may offer a novel cytoprotective modality that further augments the natural antioxidant responses in multiple sclerosis tissue and is not yet targeted by other multiple sclerosis therapies.

TL;DR: Analyses in the animal model of experimental autoimmune encephalomyelitis (EAE) demonstrate that laquinimod reduces infiltration of leukocytes into the central nervous system, induces a Th1 to Th2/3 shift, and suppresses Th17 responses, consistent with immunomodulatory properties.

TL;DR: The ability of 7,8-DHF to imitate BDNF function in motoneurons by using Trk receptor signaling would provide a new approach for the treatment of motoneuron diseases, but needs a more detailed analysis of the activation profile of 6,7-D HF.

TL;DR: The results indicate that molecules of the ECM, especially chondroitin sulfates, play an important role as axon growth‐promoting cues, and could demonstrate a modifying effect of the matrix components on motoneuron survival and caspase3‐induced apoptosis.

TL;DR: Motoneurons from the embryonic spinal cord can be isolated by this method, survive and grow out neurites, and the following method describes an alternative technique using wheat germ agglutinin for a preplating procedure instead of the p75NTR antibody.