R
Rebecca Y. Lai
Researcher at University of Nebraska–Lincoln
Publications - 94
Citations - 5589
Rebecca Y. Lai is an academic researcher from University of Nebraska–Lincoln. The author has contributed to research in topics: Aptamer & Cyclic voltammetry. The author has an hindex of 35, co-authored 86 publications receiving 4975 citations. Previous affiliations of Rebecca Y. Lai include University of California, Santa Barbara & California State University, Los Angeles.
Papers
More filters
Journal ArticleDOI
An Electronic, Aptamer-Based Small-Molecule Sensor for the Rapid, Label-Free Detection of Cocaine in Adulterated Samples and Biological Fluids
Brian R. Baker,Rebecca Y. Lai,McCall S. Wood,Elaine H. Doctor,Alan J. Heeger,Kevin W. Plaxco +5 more
TL;DR: The sensor, based on the electrochemical interrogation of a structure-switching aptamer, specifically detects micromolar cocaine in seconds and may be readily adapted for the detection of other small molecules of a wide range of clinically and environmentally relevant small molecules.
Journal ArticleDOI
Aptamer-Based Electrochemical Detection of Picomolar Platelet-Derived Growth Factor Directly in Blood Serum
TL;DR: An electrochemical, aptamer-based (E-AB) sensor for the detection of platelet-derived growth factor (PDGF) directly in blood serum that employs alternating current voltammetry to monitor target-induced folding in a methylene blue-modified, PDGF-binding aptamer.
Journal ArticleDOI
Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing.
TL;DR: This protocol describes the fabrication of E-DNA and E-AB sensors, which are comprised of an oligonucleotide probe modified with a redox reporter at one terminus and attached to a gold electrode via a thiol-gold bond at the other.
Journal ArticleDOI
Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor.
James Swensen,Yi Xiao,Brian Scott Ferguson,Arica A. Lubin,Rebecca Y. Lai,Alan J. Heeger,Kevin W. Plaxco,H. Tom Soh +7 more
TL;DR: The approach of integrating folding-based electrochemical sensors with miniaturized detection systems may lay the groundwork for the real-time, point-of-care detection of a wide variety of molecular targets.
Journal ArticleDOI
Effect of Molecular Crowding on the Response of an Electrochemical DNA Sensor
TL;DR: The results suggest that E-DNA signaling arises due to hybridization-linked changes in the rate, and thus efficiency, with which the redox moiety collides with the electrode and transfers electrons.