R
Rebekka Schwab
Researcher at University of Bern
Publications - 3
Citations - 193
Rebekka Schwab is an academic researcher from University of Bern. The author has contributed to research in topics: Cell cycle & CHUK. The author has an hindex of 3, co-authored 3 publications receiving 180 citations.
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Journal ArticleDOI
Hijacking of host cell IKK signalosomes by the transforming parasite Theileria
Volker Heussler,Sven Rottenberg,Rebekka Schwab,Peter Küenzi,Paula C. Fernandez,Susan McKellar,Brian Shiels,Zhijian J. Chen,Kim Orth,David Wallach,Dirk A. E. Dobbelaere +10 more
TL;DR: This work found that survival of Theileria-transformed leukocytes depends strictly on constitutive nuclear factor kappa B activity and found that this was mediated by recruitment of the multisubunit IκB kinase into large, activated foci on the parasite surface.
Journal ArticleDOI
The Akt/PKB pathway is constitutively activated in Theileria-transformed leucocytes, but does not directly control constitutive NF-kappaB activation.
Volker Heussler,Peter Küenzi,Felix Fraga,Rebekka Schwab,Brian A. Hemmings,Dirk A. E. Dobbelaere +5 more
TL;DR: It is shown that the two pathways are downregulated with different kinetics when the parasite is eliminated from the host cell cytoplasm and that NF‐κB‐dependent protection against apoptosis is not dependent on a functional PI3‐K‐Akt/PKB pathway.
Journal ArticleDOI
The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions.
Hana Blazkova,Conrad von Schubert,Keith Mikule,Rebekka Schwab,Nico Angliker,Jacqueline Schmuckli-Maurer,Paula C. Fernandez,Stephen J. Doxsey,Dirk A. E. Dobbelaere +8 more
TL;DR: It is shown that BMS-345541 affects several mitotic cell-cycle transitions, including mitotic entry, prometaphase to anaphase progression and cytokinesis, and the newly discovered level of BMS 345541 function may provide valuable clues for the design of future therapeutics.