R
Reem K. Arafa
Researcher at University of Science and Technology of China
Publications - 82
Citations - 1573
Reem K. Arafa is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 21, co-authored 67 publications receiving 1213 citations. Previous affiliations of Reem K. Arafa include Cairo University & University of North Carolina at Chapel Hill.
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In vitro anticancer screening and radiosensitizing evaluation of some new quinolines and pyrimido[4,5-b]quinolines bearing a sulfonamide moiety.
TL;DR: The present work reports the synthesis of twenty novel quinoline and pyrimido[4,5-b]quinoline derivatives bearing a sulfonamide moiety designed in compliance with the general pharmacophoric requirements for CA inhibiting anticancer drugs, as this may play a role in their anticancer activity.
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Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
Mohamed A. Ismail,Reem K. Arafa,Tanja Wenzler,Reto Brun,Farial A. Tanious,W. David Wilson,David W. Boykin +6 more
TL;DR: The key dinitrile intermediates 4a-d were synthesized by reaction of phenacyl bromide 1 and the appropriate 2-amino-5-bromopyridines to yield 3a-D, and two of the diamidines 7c and 7d were slightly more active than furamidine but less active than azafuramidine in the T. r.
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Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
Mohamed A. Ismail,Reem K. Arafa,Reto Brun,Tanja Wenzler,Yi Miao,W. David Wilson,Claudia N. Generaux,Arlene S. Bridges,James Edwin Hall,David W. Boykin +9 more
TL;DR: Mouse liver microsome bioconversion of the methamidoxime prodrugs is significantly reduced from that of pafuramidine and suggests that the in vivo efficacy of these prodrugS is, in part, due to poor bioconversions.
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Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
Reem K. Arafa,Reto Brun,Tanja Wenzler,Farial A. Tanious,W. David Wilson,Chad E. Stephens,David W. Boykin +6 more
TL;DR: DNA binding studies suggest that the diguanidines and the N-alkyl diguanIDines fluorenes bind in the minor groove in a manner similar to that of the previously reported dicationic carbazole derivatives.
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Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Manoj Munde,Mohamed A. Ismail,Reem K. Arafa,Paul Peixoto,Catharine J. Collar,Yang Liu,Laixing Hu,Marie-Hélène David-Cordonnier,Amélie Lansiaux,Christian Bailly,David W. Boykin,W. David Wilson +11 more
TL;DR: Molecular modeling studies support a minor groove complex and provide an inter-compound and compound-DNA hydrogen-bonding rational for the unusual GC binding specificity and the requirement for a pyrimidine heterocycle.