R
Régis Brion
Researcher at University of Nantes
Publications - 56
Citations - 3396
Régis Brion is an academic researcher from University of Nantes. The author has contributed to research in topics: Osteosarcoma & Cytokine. The author has an hindex of 27, co-authored 53 publications receiving 2862 citations. Previous affiliations of Régis Brion include French Institute of Health and Medical Research.
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Journal ArticleDOI
Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling
Pierre J. Guihard,Yannic Danger,Bénédicte Brounais,Bénédicte Brounais,Emmanuelle David,Emmanuelle David,Régis Brion,Régis Brion,Joel Delecrin,Carl D. Richards,Sylvie Chevalier,François Rédini,François Rédini,Dominique Heymann,Dominique Heymann,Hugues Gascan,Frédéric Blanchard,Frédéric Blanchard +17 more
TL;DR: It is proposed that during bone inflammation, infection, or injury, the IL‐6 family signaling network activated by macrophages and TLR ligands stimulates bone formation that is largely uncoupled from bone resorption and is thus an important target for anabolic bone therapies.
Journal ArticleDOI
A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells.
Dominique Chabannes,Marcelo Hill,Emmanuel Merieau,Julien Rossignol,Régis Brion,Jean-Paul Soulillou,Jean-Paul Soulillou,Ignacio Anegon,Maria-Cristina Cuturi +8 more
TL;DR: It is shown, for the first time, that heme oxygenase-1 mediates the immunosuppressive properties of rat and human MSCs.
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Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression.
Christine Chauveau,Séverine Remy,Pierre Joseph Royer,Marcelo Hill,Séverine Tanguy-Royer,François-Xavier Hubert,Laurent Tesson,Régis Brion,Gaelle Beriou,Marc Grégoire,Régis Josien,Maria-Cristina Cuturi,Ignacio Anegon +12 more
TL;DR: The capacity of HO-1 is identified, for the first time, to block maturation of DCs and to inhibit proinflammatory and allogeneic immune responses while preserving IL-10 production.
Journal ArticleDOI
Human breast cancer cells educate macrophages toward the M2 activation status
Sofia Sousa,Régis Brion,Régis Brion,Minnamaija Lintunen,Pauliina Kronqvist,Jouko Sandholm,Jukka Mönkkönen,Pirkko-Liisa Kellokumpu-Lehtinen,Susanna Lauttia,Olli Tynninen,Heikki Joensuu,Dominique Heymann,Dominique Heymann,Jorma A. Määttä,Jorma A. Määttä +14 more
TL;DR: It is demonstrated ex vivo that breast cancer cell-secreted factors modulate macrophage differentiation toward the M2 phenotype and that TAM differentiation status correlates with recurrence free survival, thus further emphasizing that TAMs can similarly affect therapy efficacy and patient outcome.
Journal ArticleDOI
Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment
Aude I. Segaliny,Amel Mohamadi,Amel Mohamadi,Blandine Dizier,Blandine Dizier,Anna Lokajczyk,Anna Lokajczyk,Régis Brion,Régis Brion,Rachel Lanel,Rachel Lanel,Jérôme Amiaud,Jérôme Amiaud,Céline Charrier,Céline Charrier,Catherine Boisson-Vidal,Catherine Boisson-Vidal,Dominique Heymann,Dominique Heymann +18 more
TL;DR: It is demonstrated that IL‐34 is expressed by osteosarcoma cells, is regulated by TNF‐α, IL‐1β, and contributes to osteosARcoma growth by increasing the neo‐angiogenesis and the recruitment of M2 macrophages.