R
Reinaldo González-Ramos
Researcher at University of Chile
Publications - 18
Citations - 1027
Reinaldo González-Ramos is an academic researcher from University of Chile. The author has contributed to research in topics: Endometriosis & Endometrium. The author has an hindex of 13, co-authored 18 publications receiving 871 citations. Previous affiliations of Reinaldo González-Ramos include Université catholique de Louvain.
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Journal ArticleDOI
Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis.
Reinaldo González-Ramos,Jacques Donnez,Sylvie Defrère,Isabelle Leclercq,Jean Squifflet,Jean-Christophe Lousse,Anne Van Langendonckt +6 more
TL;DR: Constitutive NF-kappaB activation, involving p65- and p50-containing dimers, was demonstrated in peritoneal endometriotic lesions by electrophoretic mobility shift assays and supershift analyses, as well as NF- kappaB (p65) DNA-binding activity immunodetection assays.
Journal ArticleDOI
Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis.
Reinaldo González-Ramos,Anne Van Langendonckt,Sylvie Defrère,Jean-Christophe Lousse,Sébastien Colette,Luigi Devoto,Jacques Donnez +6 more
TL;DR: In this article, the role of NF-κB in the pathogenesis of endometriosis has been evaluated using a literature search conducted in PubMed to identify all relevant citations, highlighting the important role of NGF in the pathwayophysiology of Endometria.
Journal ArticleDOI
Potential involvement of iron in the pathogenesis of peritoneal endometriosis
Sylvie Defrère,Jean-Christophe Lousse,Reinaldo González-Ramos,Sébastien Colette,Jacques Donnez,A. Van Langendonckt +5 more
TL;DR: Excess iron accumulation can result in toxicity and may be one of the factors contributing to the development of endometriosis, so treatment with an iron chelator could be beneficial in endometiosis patients to prevent iron overload in the pelvic cavity, thereby diminishing its deleterious effect.
Journal ArticleDOI
Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology
TL;DR: The scientific evidence strongly suggests that NF-κB activity in endometriotic cells stimulates inflammation and cell proliferation and inhibits apoptosis, favoring the development and maintenance of endometRIosis.
Journal ArticleDOI
Increased activation of nuclear factor-kappa B (NF-kappaB) in isolated peritoneal macrophages of patients with endometriosis.
Jean-Christophe Lousse,Anne Van Langendonckt,Reinaldo González-Ramos,Sylvie Defrère,Emmanuelle Renkin,Jacques Donnez +5 more
TL;DR: Results show that activation of nuclear factor-kappa B (NF-KappaB), a pro-inflammatory transcription factor, is statistically significantly increased in peritoneal macrophages from patients with endometriosis when compared with controls.