Reinhard Büttner

TL;DR: In this paper, a promising approach for the label-free analysis of DNA molecules using direct probing of the binding state of DNA with electromagnetic waves at THz frequencies is reported, which provides a drastically enhanced sensitivity enabling analysis down to femtomol levels.

TL;DR: Time-resolved terahertz transmission analysis of polynucleotides demonstrates a strong dependence of the complex refractive index on the binding state (hybridized/denatured) of deoxyribonucleic acid (DNA) molecules, which can be inferred by monitoring THz transients and hence identify polyn nucleotides by detecting the binding of unknown polyn DNA sequences to known probe molecules.

TL;DR: This is the first study that reports the long-term outcome of ARPKD patients with defined PK HD1 mutations, indicating that PKHD1 mutation screening is a powerful diagnostic tool in patients suspected with AR PKD.

TL;DR: This study was performed to evaluate histone lysine and histone acetyl modifications in prostate tissue to evaluate their predictors of cancer recurrence in various tumor entities.

TL;DR: The aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell‐free serum DNA of prostate cancer (PCA) patients.