J
Jutta Kirfel
Researcher at University of Bonn
Publications - 111
Citations - 4805
Jutta Kirfel is an academic researcher from University of Bonn. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 35, co-authored 95 publications receiving 4150 citations. Previous affiliations of Jutta Kirfel include Hannover Medical School & RWTH Aachen University.
Papers
More filters
Journal ArticleDOI
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
Soyoung Lim,Andreas Janzer,Astrid Becker,Andreas Zimmer,Roland Schüle,Reinhard Buettner,Jutta Kirfel +6 more
TL;DR: The data indicate that LSD1 may provide a predictive marker for aggressive biology and a novel attractive therapeutic target for treatment of ER-negative breast cancers.
Journal ArticleDOI
Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
Johannes H. Schulte,Soyoung Lim,Alexander Schramm,Nicolaus Friedrichs,Jan Koster,Rogier Versteeg,Ingrid Øra,Kristian W. Pajtler,Ludger Klein-Hitpass,Steffi Kuhfittig-Kulle,Eric Metzger,Roland Schüle,Angelika Eggert,Reinhard Buettner,Jutta Kirfel +14 more
TL;DR: First evidence that a histone demethylase, LSD1, is involved in maintaining the undifferentiated, malignant phenotype of neuroblastoma cells is provided, showing that inhibition of LSD1 reprograms the transcriptome of neuro Blastoma cells and inhibits Neuroblastoma xenograft growth in vivo.
Journal ArticleDOI
Phosphorylation of histone H3T6 by PKCβ I controls demethylation at histone H3K4
Eric Metzger,Axel Imhof,Dharmeshkumar Patel,Philip Kahl,Katrin Hoffmeyer,Nicolaus Friedrichs,Judith M. Müller,Holger Greschik,Jutta Kirfel,Sujuan Ji,Natalia Kunowska,Christian Beisenherz-Huss,Thomas Günther,Reinhard Buettner,Roland Schüle +14 more
TL;DR: In this paper, the authors show that phosphorylation of histone H3 at threonine 6 (H3T6) by protein kinase C beta I (PKCbeta(I), also known as PRKCbeta) is the key event that prevents LSD1 from demethylating H3K4 during AR-dependent gene activation.
Journal ArticleDOI
Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD).
Carsten Bergmann,Jan Senderek,Ellen Windelen,Fabian Küpper,Iris Middeldorf,Frank Schneider,Christian Dornia,Sabine Rudnik-Schöneborn,Martin Konrad,Claus Peter Schmitt,Tomas Seeman,Thomas Neuhaus,Udo Vester,Jutta Kirfel,Reinhard Büttner,Klaus Zerres +15 more
TL;DR: This is the first study that reports the long-term outcome of ARPKD patients with defined PK HD1 mutations, indicating that PKHD1 mutation screening is a powerful diagnostic tool in patients suspected with AR PKD.
Journal ArticleDOI
Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy.
Jan Senderek,Carsten Bergmann,Claudia Stendel,Jutta Kirfel,Nathalie Verpoorten,Peter De Jonghe,Vincent Timmerman,Roman Chrast,Mark H.G. Verheijen,Greg Lemke,Esra Battaloglu,Yesim Parman,Sevim Erdem,Ersin Tan,Haluk Topaloglu,Andreas Hahn,Wolfgang Müller-Felber,Nicolo' Rizzuto,Gian Maria Fabrizi,Manfred Stuhrmann,Sabine Rudnik-Schöneborn,Stephan Züchner,J. Michael Schröder,Eckhard Buchheim,Volker Straub,Jörg Klepper,Kathrin Huehne,Bernd Rautenstrauss,Reinhard Büttner,Eva Nelis,Klaus Zerres +30 more
TL;DR: Comparative sequence alignments indicate that members of this protein family contain multiple SH3 and TPR domains that are likely involved in the formation of protein complexes, and defines a new protein family of unknown function with putative orthologues in vertebrates.