R
Reinhard Büttner
Researcher at University Hospital Bonn
Publications - 55
Citations - 2727
Reinhard Büttner is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: Prostate cancer & Carcinoma. The author has an hindex of 18, co-authored 55 publications receiving 2532 citations. Previous affiliations of Reinhard Büttner include RWTH Aachen University & University Medical Center Freiburg.
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Integrated THz technology for label-free genetic diagnostics
Michael Nagel,P. Haring Bolivar,M. Brucherseifer,Heinrich Kurz,Anja-Katrin Bosserhoff,Reinhard Büttner +5 more
TL;DR: In this paper, a promising approach for the label-free analysis of DNA molecules using direct probing of the binding state of DNA with electromagnetic waves at THz frequencies is reported, which provides a drastically enhanced sensitivity enabling analysis down to femtomol levels.
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Label-free probing of the binding state of DNA by time-domain terahertz sensing
M. Brucherseifer,Michael Nagel,P. Haring Bolivar,Heinrich Kurz,Anja-Katrin Bosserhoff,Reinhard Büttner +5 more
TL;DR: Time-resolved terahertz transmission analysis of polynucleotides demonstrates a strong dependence of the complex refractive index on the binding state (hybridized/denatured) of deoxyribonucleic acid (DNA) molecules, which can be inferred by monitoring THz transients and hence identify polyn nucleotides by detecting the binding of unknown polyn DNA sequences to known probe molecules.
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Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD).
Carsten Bergmann,Jan Senderek,Ellen Windelen,Fabian Küpper,Iris Middeldorf,Frank Schneider,Christian Dornia,Sabine Rudnik-Schöneborn,Martin Konrad,Claus Peter Schmitt,Tomas Seeman,Thomas Neuhaus,Udo Vester,Jutta Kirfel,Reinhard Büttner,Klaus Zerres +15 more
TL;DR: This is the first study that reports the long-term outcome of ARPKD patients with defined PK HD1 mutations, indicating that PKHD1 mutation screening is a powerful diagnostic tool in patients suspected with AR PKD.
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Global levels of histone modifications predict prostate cancer recurrence
Jörg Ellinger,Philip Kahl,Johannes von der Gathen,Sebastian Rogenhofer,Lukas C. Heukamp,Ines Gütgemann,Bernhard Walter,Ferdinand Hofstädter,Reinhard Büttner,Stefan C. Müller,Patrick J. Bastian,Alexander von Ruecker +11 more
TL;DR: This study was performed to evaluate histone lysine and histone acetyl modifications in prostate tissue to evaluate their predictors of cancer recurrence in various tumor entities.
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CpG Island Hypermethylation in Cell-Free Serum DNA Identifies Patients With Localized Prostate Cancer
Jörg Ellinger,Kim Haan,Lukas C. Heukamp,Philip Kahl,Reinhard Büttner,Stefan C. Müller,Alexander von Ruecker,Patrick J. Bastian +7 more
TL;DR: The aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell‐free serum DNA of prostate cancer (PCA) patients.