R
Reinhard Kappl
Researcher at Saarland University
Publications - 75
Citations - 2518
Reinhard Kappl is an academic researcher from Saarland University. The author has contributed to research in topics: Electron paramagnetic resonance & Radical. The author has an hindex of 27, co-authored 69 publications receiving 2148 citations. Previous affiliations of Reinhard Kappl include University of Münster & University of Oldenburg.
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Journal ArticleDOI
Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure
Alexander Nickel,Albrecht von Hardenberg,Mathias Hohl,Joachim Löffler,Michael Kohlhaas,Janne Becker,Jan Christian Reil,Andrey Kazakov,Julia Bonnekoh,Moritz Stadelmaier,Sarah Lena Puhl,Michael Wagner,Ivan Bogeski,Sonia Cortassa,Reinhard Kappl,Bastian Pasieka,Michael Lafontaine,C. Roy D. Lancaster,Thomas S. Blacker,Andrew R. Hall,Michael R. Duchen,Lars Kästner,Peter Lipp,Tanja Zeller,Christian P. Müller,Andreas Knopp,Ulrich Laufs,Michael Böhm,Markus Hoth,Christoph Maack +29 more
TL;DR: It is shown that pathological metabolic demand reverses the direction of the Nnt, consuming NADPH to support NADH and ATP production, but at the cost of NADPH-linked antioxidative capacity.
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Square-Wave Voltammetry: A Review on the Recent Progress
TL;DR: In this paper, a review on the recent progress of square-wave voltammetry is presented, covering the period of the last five years, addressing the new theoretical development of the technique as well as its application for mechanistic purposes, electrode kinetic measurements, biochemical and analytical applications.
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Reconstitution and characterization of the polynuclear iron-sulfur cluster in pyruvate formate-lyase-activating enzyme. Molecular properties of the holoenzyme form.
TL;DR: The iron-sulfur cluster complement proved to be a prerequisite for effective binding of adenosylmethionine, which induces a characteristic shift of the EPR signal shape of the reduced enzyme form ([4Fe-4S]+) from axial to rhombic symmetry.
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Redox regulation of calcium ion channels: Chemical and physiological aspects
Ivan Bogeski,Reinhard Kappl,Carsten Kummerow,Rubin Gulaboski,Markus Hoth,Barbara A. Niemeyer +5 more
TL;DR: Basic oxygen redox chemistry and methods of ROS detection with special emphasis on electron paramagnetic resonance (EPR) spectroscopy are reviewed and the present knowledge of redox regulation of Ca(2+) permeable ion channels such as voltage-gated Ca( 2+) channels, transient receptor potential (TRP) channels and Orai channels is focused on.
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Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy
Britta Stapel,Michael Kohlhaas,Melanie Ricke-Hoch,Arash Haghikia,Sergej Erschow,Juhani Knuuti,Johanna M.U. Silvola,Anne Roivainen,Antti Saraste,Alexander Nickel,Jasmin A. Saar,Irina Sieve,Stefan Pietzsch,Mirco Müller,Ivan Bogeski,Reinhard Kappl,Matti Jauhiainen,James T. Thackeray,Michaela Scherr,Frank M. Bengel,Christian Hagl,Igor Tudorache,Johann Bauersachs,Christoph Maack,Denise Hilfiker-Kleiner +24 more
TL;DR: Iso impairs glucose uptake, induces energy depletion, oxidative stress, dysfunction, and death in STAT3-deficient cardiomyocytes mainly via β1-AR stimulation, which may underlie the dobutamine-induced irreversible heart failure progression in PPCM patients who frequently display reduced cardiac STAT3 expression.