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Michael R. Duchen

Researcher at University College London

Publications -  266
Citations -  36713

Michael R. Duchen is an academic researcher from University College London. The author has contributed to research in topics: Mitochondrion & Mitochondrial permeability transition pore. The author has an hindex of 95, co-authored 256 publications receiving 32541 citations. Previous affiliations of Michael R. Duchen include Utrecht University & Royal Veterinary College.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

Edward T. Chouchani, +29 more
- 20 Nov 2014 - 
TL;DR: In this article, a comparative in vivo metabolomic analysis was conducted to identify widely conserved metabolic pathways responsible for mitochondrial reactive oxygen species (ROS) production during ischaemia reperfusion.
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Mitochondria and calcium: from cell signalling to cell death

Michael R. Duchen
- 01 Nov 2000 - 
TL;DR: Accumulation of Ca2+ into mitochondria regulates mitochondrial metabolism and causes a transient depolarisation of mitochondrial membrane potential, and alteration of spatiotemporal characteristics of cellular [Ca2+]c signalling and downregulates mitochondrial metabolism.

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

EE Chouchani, +9 more
TL;DR: It is shown that selective accumulation of the citric acid cycle intermediate succinate is a universal metabolic signature of ischaemia in a range of tissues and is responsible for mitochondrial ROS production during reperfusion, and a new pathway for metabolic control of ROS production in vivo is revealed.
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Mitochondria in health and disease: perspectives on a new mitochondrial biology.

Michael R. Duchen
- 01 Aug 2004 - 
TL;DR: In this review, recent developments in knowledge of basic aspects of mitochondrial biology are considered as an essential step in developing understanding of the contributions of mitochondria to disease.