R
Renate Hellmiss
Researcher at Genentech
Publications - 10
Citations - 3102
Renate Hellmiss is an academic researcher from Genentech. The author has contributed to research in topics: Guanylate cyclase 2C & Peptide sequence. The author has an hindex of 10, co-authored 10 publications receiving 3041 citations. Previous affiliations of Renate Hellmiss include Harvard University.
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Journal ArticleDOI
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.
TL;DR: Catalytic amounts of rhDNase greatly reduce the viscosity of purulent cystic fibrosis sputum, transforming it within minutes from a nonflowing viscous gel to a flowing liquid.
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Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.
Paul J. Godowski,David W. Leung,Lillian R. Meacham,John P. Galgani,Renate Hellmiss,Ruth Keret,Peter Rotwein,John S. Parks,Zvi Laron,William I. Wood +9 more
TL;DR: Characterization of the growth hormone receptor gene from nine patients with Laron-type dwarfism shows that two individuals have a deletion of a large portion of the extracellular, hormone binding domain of the receptor gene.
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Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases
TL;DR: The cloning and expression of a second human natriuretic peptide-receptor guanylate cyclase, the ANP-B receptor, is reported, which is preferentially activated by porcine brain natriuric peptide rather than human α-ANP, and may have important implications for the understanding of the central and peripheral control of cardiovascular homeostasis.
Journal ArticleDOI
Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein
William I. Wood,George Cachianes,William J. Henzel,Genine A. Winslow,Steven A. Spencer,Renate Hellmiss,Janet L. Martin,Robert C. Baxter +7 more
TL;DR: The deduced protein sequence of BP-53 has 33% amino acid identity including conservation of all 18 cysteine residues with the recently cloned BP-28, a smaller human IGF-binding protein identified in amniotic fluid and also secreted by the cell line HEP G2.
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Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction.
David G. Lowe,Ming-Shi Chang,Renate Hellmiss,Ellson Y. Chen,S. Singh,David L. Garbers,David V. Goeddel +6 more
TL;DR: A new paradigm of cellular signal transduction where extracellular ligand binding allosterically regulates cyclic nucleotide second‐messenger production by a receptor cytoplasmic catalytic domain is demonstrated.