Steven A. Spencer

TL;DR: The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.

TL;DR: A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned and binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily.

TL;DR: Human tumor necrosis factor was purified to homogeneity from serum-free tissue culture supernatants of the HL-60 promyelocytic leukemia cell line induced by 4 beta-phorbol 12-myristate 13-acetate.

TL;DR: The deduced protein sequence of BP-53 has 33% amino acid identity including conservation of all 18 cysteine residues with the recently cloned BP-28, a smaller human IGF-binding protein identified in amniotic fluid and also secreted by the cell line HEP G2.

TL;DR: It is found that PC-1 activity is increased in fibroblasts from seven of nine patients with typical non-insulin-dependent diabetes mellitus, and overexpression of PC- 1 in transfected cultured cells reduces insulin-stimulated tyrosine kinase activity.