Health effects of quercetin: from antioxidant to nutraceutical.

https://ucanr.edu/datastoreFiles/608-68.pdf

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties.

Pyrethroids: exposure and health effects--an update

The flavonoid quercetin is frequently found in low amounts as a secondary plant metabolite in fruits and vegetables. Isolated quercetin is also marketed as a dietary supplement, mostly as the free quercetin aglycone, and frequently in daily doses of up to 1000 mg d-1 exceeding usual dietary intake levels. The present review is dedicated to safety aspects of isolated quercetin used as single compound in dietary supplements. Among the numerous published human intervention studies, adverse effects following supplemental quercetin intake have been rarely reported and any such effects were mild in nature. Published adequate scientific data for safety assessment in regard to the long-term use (>12 weeks) of high supplemental quercetin doses (≥1000 mg) are currently not available. Based on animal studies involving oral quercetin application some possible critical safety aspects could be identified such as the potential of quercetin to enhance nephrotoxic effects in the predamaged kidney or to promote tumor development especially in estrogen-dependent cancer. Furthermore, animal and human studies with single time or short-term supplemental quercetin application revealed interactions between quercetin and certain drugs leading to altered drug bioavailability. Based on these results, some potential risk groups are discussed in the present review.

Safety Aspects of the Use of Quercetin as a Dietary Supplement.

Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes.

The relationship of 3-PBA pyrethroids metabolite and male reproductive hormones among non-occupational exposure males.

Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males.

Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and thyroid hormone levels in Chinese non-occupational exposure adult males

The aim of this study was to investigate the preventive effects of quercetin against benzo[a]pyrene-induced blood lymphocyte DNA damages and pulmonary precancerous pathologic changes in mice, and to reveal the potential mechanism behind these effects. In this study, mice in quercetin-treated groups were given quercetin for 90 days. After one week of treatment, mice in the quercetin-treated groups and the positive control group received a single intraperitoneal dose of benzo[a]pyrene (100 mg/kg body weight). The results of single cell gel electrophoresis assay showed that the average lengths of the comet cell tail and DNA damage in the peripheral blood lymphocytes of mice induced by benzo[a]pyrene decreased significantly as a result of quercetin treatment dose-dependently. Light microscopic examination showed that the degrees of pulmonary precancerous pathologic changes in the quercetin-treated groups decreased significantly compared with those in the positive control group. Meanwhile, the cytochrome P4501A1-linked 7-ethoxyresorufin O-dealkylase activities in lung microsomes of mice decreased as the dose of quercetin increased. The results of this in vivo study revealed that quercetin had a significant preventive effect on benzo[a]pyrene-induced DNA damage, and had a potential chemopreventive effect on the carcinogenesis of lung cancer induced by benzo[a]pyrene. The mechanism of these effects of quercetin could be related to the inhibition of cytochrome P4501A1 activity.

/pdf/preventive-effects-of-quercetin-against-benzo-a-pyrene-5argxptp2s.pdf

Preventive effects of quercetin against benzo[a]pyrene-induced DNA damages and pulmonary precancerous pathologic changes in mice.

细胞色素P4501A1(CYP 1A1)与癌症的关系十分密切,许多化学致癌物均需经CYP 1A1代谢活化后才能发挥其致癌作用槲皮素(Quercetin,Que)具有抗炎、抗过敏、抗肿瘤等多种生物活性及药理作用啮齿类动物实验显示槲皮素能抑制致癌剂、促癌剂的致癌、促癌作用[1]但由于人肝标本的缺乏,故以往对槲皮素的抗癌作用研究主要集中在细胞或动物实验上我们对人肝L-02细胞和人肝组织的9乙氧基-3异吩噁唑酮-0-脱乙基酶(EROD)活性进行了比较,初步探讨细胞株和人肝组织在生物学实验上是否存在一定程度的差异。

Rencheng Zhao

Papers

The relationship of 3-PBA pyrethroids metabolite and male reproductive hormones among non-occupational exposure males.

Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males.

Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and thyroid hormone levels in Chinese non-occupational exposure adult males

Preventive effects of quercetin against benzo[a]pyrene-induced DNA damages and pulmonary precancerous pathologic changes in mice.

[Effect of quercetin on the activities of cytochrome p450 1A1 in L-02 cell lines and human liver microsomes].