R
Rency S. Varghese
Researcher at Georgetown University Medical Center
Publications - 70
Citations - 1989
Rency S. Varghese is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Biomarker discovery & Medicine. The author has an hindex of 21, co-authored 61 publications receiving 1732 citations. Previous affiliations of Rency S. Varghese include University of Maine & University of Washington.
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Journal ArticleDOI
Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis.
Habtom W. Ressom,Jun Feng Xiao,Leepika Tuli,Rency S. Varghese,Bin Zhou,Tsung-Heng Tsai,Mohammad R. Nezami Ranjbar,Yi Zhao,Jinlian Wang,Cristina Di Poto,Amrita K. Cheema,Mahlet G. Tadesse,Radoslav Goldman,Kirti Shetty +13 more
TL;DR: Comparison of metabolite levels in sera of 78 HCC cases with 184 cirrhotic controls by using ultra performance liquid chromatography coupled with a hybrid quadrupole time-of-flight mass spectrometry provides useful insights into HCC biomarker discovery utilizing metabolomics as an efficient and cost-effective platform.
Journal ArticleDOI
Enrichment of low molecular weight fraction of serum for MS analysis of peptides associated with hepatocellular carcinoma
Eduard Orvisky,Steven K. Drake,Brian M. Martin,Mohamed Abdel-Hamid,Habtom W. Ressom,Rency S. Varghese,Yanming An,Daniel T. Saha,Glen L. Hortin,Christopher A. Loffredo,Radoslav Goldman +10 more
TL;DR: It is shown that enrichment of the low molecular weight fraction of serum facilitates an efficient discovery of peptides that could serve as biomarkers for detection of HCC as well as other diseases.
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Detection of hepatocellular carcinoma using glycomic analysis.
Radoslav Goldman,Habtom W. Ressom,Rency S. Varghese,Lenka Goldman,Gregory Bascug,Christopher A. Loffredo,Mohamed Abdel-Hamid,Iman Gouda,Sameera Ezzat,Zuzana Kyselova,Yehia Mechref,Milos V. Novotny +11 more
TL;DR: A set of three identified N-glycans is sufficient for the detection of HCC with 90% prediction accuracy in a population with high rates of hepatitis C viral infection.
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LC-MS based serum metabolomics for identification of hepatocellular carcinoma biomarkers in Egyptian cohort.
Jun Feng Xiao,Rency S. Varghese,Bin Zhou,Mohammad R. Nezami Ranjbar,Yi Zhao,Tsung-Heng Tsai,Cristina Di Poto,Jinlian Wang,David S. Goerlitz,Yue Luo,Amrita K. Cheema,Naglaa I. Sarhan,Hanan Soliman,Mahlet G. Tadesse,Dina H. Ziada,Habtom W. Ressom +15 more
TL;DR: This is the first MS-based metabolic biomarker discovery study on Egyptian subjects that led to the identification of candidate metabolites that discriminate early stage HCC from patients with liver cirrhosis.
Journal ArticleDOI
Peak selection from MALDI-TOF mass spectra using ant colony optimization
Habtom W. Ressom,Rency S. Varghese,S. K. Drake,G. L. Hortin,M. Abdel-Hamid,Christopher A. Loffredo,Radoslav Goldman +6 more
TL;DR: A novel method that combines ant colony optimization (ACO) with support vector machines (SVM) to select a small set of useful peaks is proposed for matrix-assisted laser desorption/ionization time-of-flight spectral data preprocessing and peak selection.