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Rey Arturo T. Fernandez
Researcher at University of Santo Tomas
Publications - 11
Citations - 162
Rey Arturo T. Fernandez is an academic researcher from University of Santo Tomas. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 8 publications receiving 65 citations.
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Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms.
Mark Tristan J. Quimque,Mark Tristan J. Quimque,Kin Israel Notarte,Rey Arturo T. Fernandez,Mark Andrew O. Mendoza,Rhenz Alfred D Liman,Justin Allen K. Lim,Luis Agustin E. Pilapil,Jehiel Karsten H. Ong,Adriel M. Pastrana,Abbas Khan,Dong-Qing Wei,Allan Patrick G. Macabeo +12 more
TL;DR: Nine antiviral secondary metabolites from fungi were docked onto five SARS-CoV2 enzymes involved in viral attachment, replication, post-translational modification, and host immunity evasion infection mechanisms followed by molecular dynamics simulation and in silico ADMET prediction.
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Potential Cancer- and Alzheimer's Disease-Targeting Phosphodiesterase Inhibitors from Uvaria alba: Insights from In Vitro and Consensus Virtual Screening.
Mark Tristan J. Quimque,Mark Tristan J. Quimque,Kin Israel Notarte,arianne letada,Rey Arturo T. Fernandez,Delfin Yñigo H. Pilapil,Kirstin Rhys S. Pueblos,Kirstin Rhys S. Pueblos,Jay Carl M. Agbay,Hans-Martin Dahse,Arlette Wenzel-Storjohann,Deniz Tasdemir,Deniz Tasdemir,Abbas Khan,Dong-Qing Wei,Allan Patrick G. Macabeo +15 more
TL;DR: In this paper, the authors evaluated anti-PDE4B along with antiproliferative and anti-cholinesterase activities of the extracts of the Philippine endemic species Uvaria alba using in vitro assays and framed the resulting biological significance through computational binding and reactivity-based experiments.
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Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.
Von Novi de Leon,Joe Anthony H. Manzano,Delfin Yñigo H. Pilapil,Rey Arturo T. Fernandez,James Kyle Anthony R. Ching,Mark Tristan J. Quimque,Mark Tristan J. Quimque,Jay Carl M. Agbay,Kin Israel Notarte,Allan Patrick G. Macabeo +9 more
TL;DR: In this article, the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins (nsps) was explored.
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Exploiting the Freshwater Shrimp Neocaridina denticulata as Aquatic Invertebrate Model to Evaluate Nontargeted Pesticide Induced Toxicity by Investigating Physiologic and Biochemical Parameters.
Petrus Siregar,Michael Edbert Suryanto,Kelvin H.-C. Chen,Jong-Chin Huang,Hong-Ming Chen,Kevin Adi Kurnia,Fiorency Santoso,Akhlaq Hussain,Bui Thi Ngoc Hieu,Ferry Saputra,Gilbert Audira,Marri Jmelou M. Roldan,Rey Arturo T. Fernandez,Allan Patrick G. Macabeo,Hong-Thih Lai,Chung-Der Hsiao +15 more
Abstract: As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, Neocaridina denticulata, could also be affected, thus causing adverse effects on the aquatic environment. To investigate IMI toxicity on nontarget organisms like N. denticulata, their physiology (locomotor activity, heartbeat, and gill ventilation) and biochemical factors (oxidative stress, energy metabolism) after IMI exposure were examined. IMI exposure at various concentrations (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1 ppm) to shrimp after 24, 48, 72 h led to dramatic reduction of locomotor activity even at low concentrations. Meanwhile, IMI exposure after 92 h caused reduced heartbeat and gill ventilation at high concentrations. Biochemical assays were performed to investigate oxidative stress and energy metabolism. Interestingly, locomotion immobilization and cardiac activity were rescued after acetylcholine administration. Through molecular docking, IMI demonstrated high binding affinity to nAChR. Thus, locomotor activity and heartbeat in shrimp after IMI exposure may be caused by nAChR blockade and not alterations caused by oxidative stress and energy metabolism. To summarize, N. denticulata serves as an excellent and sensitive aquatic invertebrate model to conduct pesticide toxicity assays that encompass physiologic and biochemical examinations.
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Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein.
Rey Arturo T. Fernandez,Mark Tristan J. Quimque,Mark Tristan J. Quimque,Kin Israel Notarte,Joe Anthony H. Manzano,Delfin Yñigo H. Pilapil,Von Novi de Leon,John Jeric San Jose,Omar Villalobos,Nisha Harur Muralidharan,M. Michael Gromiha,Simone Brogi,Allan Patrick G. Macabeo +12 more
TL;DR: Sarma et al. as mentioned in this paper explored via in silico approaches myxobacterial secondary metabolites against various receptor-binding regions of SARS-CoV-2 spike which are responsible in recognition and attachment to host cell receptors mechanisms.