Rhian S. Thomas

TL;DR: The data suggest that load and Wnt, in combination, can repress transcription of chondrocyte matrix genes, whilst enhancing expression of catabolic mediators.

TL;DR: The expression of proteins related to these endocytic processes in the cortex of Tg2576 mice that overexpress the Swedish mutation in APP were examined to determine if there were any changes in their associated pathways and significant increases in the levels of clathrin, dynamin and PICALM were identified in the transgenic animals.

TL;DR: The depletion of PICALM in brain-derived cells has significant effects on the processing of APP, probably by reducing CME, which affects the production of β-CTF which is increasingly considered to be an important mediator in AD independent of Aβ.

TL;DR: How levels of endocytic proteins, APP, its metabolites, secretase enzymes, and tau varied with age in cortical brain samples from men of three age ranges with no symptoms of dementia was explored.

TL;DR: This study examined whether LPS and ovalbumin co‐administration could exacerbate the airway inflammatory and functional responses to Ovalbumin in conscious guinea pigs and whether these exacerbated responses were insensitive to inhaled corticosteroid treatment with fluticasone propionate (FP).