R
Ri Yao Yang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 36
Citations - 3932
Ri Yao Yang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Galectin & Immunotherapy. The author has an hindex of 20, co-authored 33 publications receiving 3358 citations. Previous affiliations of Ri Yao Yang include Scripps Research Institute & La Jolla Institute for Allergy and Immunology.
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Journal Article
The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
Cheng-wei Chou,Ri Yao Yang,Li Chuan Chan,Ching-Fei Li,Linlin Sun,Heng Huan Lee,Pei-Chih Lee,Yuh Pyng Sher,Haoqiang Ying,Mien Chie Hung +9 more
TL;DR: This study identified glucose regulatory protein 78 (GRP78), a major endoplasmic reticulum stress responding protein, as a novel binding partner of PD-L1, and revealed its interaction with GRP78, which modulates the response to chemotherapy and correlates with poor relapse-free survival in triple-negative breast cancer.
Journal ArticleDOI
Phosphorylation and stabilization of PD-L1 by CK2 suppresses dendritic cell function.
Xixi Zhao,Yongkun Wei,Yu Yi Chu,Yintao Li,Jung-Mao Hsu,Zhou Jiang,Chunxiao Liu,Jennifer L. Hsu,Wei Chao Chang,Ri Yao Yang,Li Chuan Chan,Jingkun Qu,Shuqun Zhang,Haoqiang Ying,Dihua Yu,Mien Chie Hung +15 more
TL;DR: It is demonstrated that PD-L1 is phosphorylated and stabilized by casein kinase 2 (CK2) in cancer and dendritic cells and suggested as a potential anti-tumor treatment option to activate dendedritic cell function by blocking the CK2-PD-L 1 pathway and inhibiting Tim-3.
Journal ArticleDOI
Powering Tumor Metastasis with Recycled Fuel
TL;DR: GOLM1 is identified as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and insights into how this process is regulated are provided.
Book ChapterDOI
Galectins in immune and inflammatory diseases: Insights from experiments with galectin deficient mice
Proceedings ArticleDOI
Abstract 6527: Targeting glycosylated PD-1 induces potent anti-tumor immunity
Yu-Han Wang,Linlin Sun,Ri Yao Yang,Jielin Liu,Yufan Qiu,Jennifer L. Hsu,Jong Ho Cha,Li Chuan Chan,Jung-Mao Hsu,Heng Huan Lee,Yun-Ju Lai,Kay-Hooi Khoo,Ezra M. Chung,Chia Wei Li,Yongsoo Kim,Andrew H. Park,Yi Yang,Stephen S. Yoo,Mien Chie Hung +18 more
TL;DR: It is shown that PD-1 is extensively N-glycosylated in T cells, and the intensities of its specific glycoforms are altered upon TCR activation, which provides novel insights into the functional significance of PD- 1 glycosylation and offers a rationale for targeting glyCosylatedPD-1 as a potential strategy for immunotherapy.