Yi Yang

TL;DR: It is demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells, and inhibition of CSN5 by curcumin diminished cancer cell PD- L1 expression and sensitized cancer cells to anti-CTLA4 therapy.

TL;DR: Findings identify a non-immune checkpoint function of PD-L1 and provide an unexpected concept that GSDMC/Caspas-8 mediates non-canonical pyroptosis pathway in cancer cells, causing tumor necrosis.

TL;DR: Transmission electron microscopy images showed that exosomes isolated from the supernatant of cell cultures of MDA-MB-231 (231) human breast cancer cells and 4T1 mouse mammary tumor cells with PD-L1 expression or PD- l1 knockout by sequential centrifugation are typically spherical and membrane encapsulated with a size of 30 – 100 nm.

TL;DR: It is shown that IL-6-activated JAK1 phosphorylates programmed death-ligand 1 (PD-L 1) Tyr112, which recruits the endoplasmic reticulum-associated N-glycosyltransferase STT3A to catalyze PD-L1 glycosylation and maintain PD- L1 stability.

TL;DR: Targeting PD-L1 palmitoylation sensitized tumor cells to T-cell killing and inhibited tumor growth and played an important role in PD- L1 stability.