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Yongkun Wei
Researcher at University of Texas MD Anderson Cancer Center
Publications - 88
Citations - 10730
Yongkun Wei is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 43, co-authored 81 publications receiving 8439 citations. Previous affiliations of Yongkun Wei include Fudan University & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression
Shiping Jiao,Shiping Jiao,Weiya Xia,Hirohito Yamaguchi,Yongkun Wei,Mei-Kuang Chen,Mei-Kuang Chen,Jung Mao Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Wen Hsuan Yu,Wen Hsuan Yu,Yi Du,Heng Huan Lee,Chia Wei Li,Chao Kai Chou,Seung Oe Lim,Shih Shin Chang,Jennifer K. Litton,Banu Arun,Gabriel N. Hortobagyi,Mien Chie Hung +22 more
TL;DR: A cross-talk between PARPi and tumor-associated immunosuppression is demonstrated and evidence is provided to support the combination of PAR Pi and PD-L1 or PD-1 immune checkpoint blockade as a potential therapeutic approach to treat breast cancer.
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IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Dung Fang Lee,Hsu Ping Kuo,Hsu Ping Kuo,Chun Te Chen,Chun Te Chen,Jung Mao Hsu,Jung Mao Hsu,Chao Kai Chou,Chao Kai Chou,Yongkun Wei,Hui-Lung Sun,Long Yuan Li,Long Yuan Li,Long Yuan Li,Bo Ping,Wei Chien Huang,Xianghuo He,Jen Yu Hung,Chien-Chen Lai,Qingqing Ding,Jen Liang Su,Jer Yen Yang,Jer Yen Yang,Aysegul A. Sahin,Gabriel N. Hortobagyi,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung +28 more
TL;DR: It is shown that IKKbeta, a major downstream kinase in the TNFalpha signaling pathway, physically interacts with and phosphorylates TSC1 at Ser487 and Ser511, resulting in suppression of T SC1 and activates the mTOR pathway, enhances angiogenesis, and results in tumor development.
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Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression
Hui-Wen Lo,Sheng-Chieh Hsu,Weiya Xia,Xinyu Cao,Jin-Yuan Shih,Jin-Yuan Shih,Yongkun Wei,James L. Abbruzzese,Gabriel N. Hortobagyi,Mien Chie Hung +9 more
TL;DR: It is shown that EGF induces EGFR-expressing cancer cells to undergo a transition from the epithelial to the spindle-like mesenchymal morphology and induce cancer cell EMT via STAT3-mediated TWIST gene expression.
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Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
Yan Michael Li,Yong Pan,Yongkun Wei,Xiaoyun Cheng,Xiaoyun Cheng,Binhua P. Zhou,Ming Tan,Xiaoyan Zhou,Weiya Xia,Gabriel N. Hortobagyi,Dihua Yu,Dihua Yu,Mien Chie Hung,Mien Chie Hung +13 more
TL;DR: It is shown that HER2 enhances the expression of CXCR4, which is required for HER2-mediated invasion in vitro and lung metastasis in vivo, and this work establishes a functional link between HER2 and CX CR4 signaling pathways.
Journal ArticleDOI
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
Hui-Wen Lo,Sheng-Chieh Hsu,Mohamed Ali-Seyed,Mehmet Gunduz,Weiya Xia,Yongkun Wei,Geoffrey Bartholomeusz,Jin-Yuan Shih,Mien Chie Hung +8 more
TL;DR: It is reported that EGFR physically interacts with signal transducers and activators of transcription 3 (STAT3) in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase (iNOS) in breast carcinomas.