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Ricardo E. Dolmetsch
Researcher at Novartis
Publications - 95
Citations - 17942
Ricardo E. Dolmetsch is an academic researcher from Novartis. The author has contributed to research in topics: Voltage-dependent calcium channel & Induced pluripotent stem cell. The author has an hindex of 45, co-authored 84 publications receiving 16327 citations. Previous affiliations of Ricardo E. Dolmetsch include Allen Institute for Brain Science & Harvard University.
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Journal ArticleDOI
Calcium oscillations increase the efficiency and specificity of gene expression
TL;DR: It is reported that oscillations reduce the effective Ca2+ threshold for activating transcription factors, thereby increasing signal detection at low levels of stimulation and providing direct evidence that [Ca2+]i oscillations increase both the efficacy and the information content of Ca2+, leading to gene expression and cell differentiation.
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Differential activation of transcription factors induced by Ca2+ response amplitude and duration
TL;DR: It is reported here that the amplitude and duration of calcium signals in B lymphocytes controls differential activation of the pro–inflammatory transcriptional regulators NF-κB, c-Jun N-terminal kinase (JNK) and NFAT, revealing a mechanism by which a multifunctional second messenger such as Ca2+ can achieve specificity in signalling to the nucleus.
Journal ArticleDOI
Calcium regulation of neuronal gene expression.
Anne E. West,Wen G. Chen,Matthew B. Dalva,Ricardo E. Dolmetsch,Jon M. Kornhauser,Adam J. Shaywitz,Mari A. Takasu,Xu Tao,Michael E. Greenberg +8 more
TL;DR: This work has characterized molecular mechanisms by which neuronal membrane depolarization and subsequent calcium influx into the cytoplasm lead to the induction of new gene transcription and refined and expand the working model of activity-induced gene induction in the brain.
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MicroRNA-mediated conversion of human fibroblasts to neurons
Andrew S. Yoo,Alfred Xuyang Sun,Li Li,Aleksandr Shcheglovitov,Thomas Portmann,Yulong Li,Christopher Lee-Messer,Ricardo E. Dolmetsch,Richard W. Tsien,Gerald R. Crabtree +9 more
TL;DR: It is shown that expression of miR-9/9* and MiR-124 in human fibroblasts induces their conversion into neurons, a process facilitated by NEUROD2.
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Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway
TL;DR: A functional knock-in technique to investigate the features of LTCs that specifically couple them to the signaling pathways that regulate gene expression found that an isoleucine-glutamine motif in the carboxyl terminus of the LTC that binds Ca2-calmodulin (CaM) is critical for conveying the Ca2+ signal to the nucleus.