X
Xu Tao
Researcher at Harvard University
Publications - 5
Citations - 8854
Xu Tao is an academic researcher from Harvard University. The author has contributed to research in topics: Transcription factor & Response element. The author has an hindex of 5, co-authored 5 publications receiving 8596 citations. Previous affiliations of Xu Tao include Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Sandeep Robert Datta,Henryk Dudek,Xu Tao,Shane C. Masters,Haian Fu,Yukiko Gotoh,Michael E. Greenberg +6 more
TL;DR: It is shown that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival.
Journal ArticleDOI
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
TL;DR: The findings suggest that a CREB family member acts cooperatively with an additional transcription factor(s) to regulate BDNF transcription, and concludes that the BDNF gene is aCREB family target whose protein product functions at synapses to control adaptive neuronal responses.
Journal ArticleDOI
Calcium regulation of neuronal gene expression.
Anne E. West,Wen G. Chen,Matthew B. Dalva,Ricardo E. Dolmetsch,Jon M. Kornhauser,Adam J. Shaywitz,Mari A. Takasu,Xu Tao,Michael E. Greenberg +8 more
TL;DR: This work has characterized molecular mechanisms by which neuronal membrane depolarization and subsequent calcium influx into the cytoplasm lead to the induction of new gene transcription and refined and expand the working model of activity-induced gene induction in the brain.
Journal ArticleDOI
A Calcium-Responsive Transcription Factor, CaRF, that Regulates Neuronal Activity-Dependent Expression of BDNF
TL;DR: The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.
Journal ArticleDOI
Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.
Wen G. Chen,Anne E. West,Xu Tao,Gabriel Corfas,Marilyn N. Szentirmay,Michèle Sawadogo,Charles Vinson,Michael E. Greenberg +7 more
TL;DR: It is found that the transcriptional activity of the USFs is regulated by Ca2+-activated signaling pathways in neurons and that theUSFs bind to the promoters of a number of neuronal activity-regulated genes in vivo, suggesting a new function for the USF in the regulation of activity-dependent transcription in neurons.