C
Christopher C. Goodnow
Researcher at Garvan Institute of Medical Research
Publications - 329
Citations - 38563
Christopher C. Goodnow is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Antigen & B cell. The author has an hindex of 92, co-authored 312 publications receiving 35069 citations. Previous affiliations of Christopher C. Goodnow include Case Western Reserve University & Australian Cancer Research Foundation.
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Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
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Differential activation of transcription factors induced by Ca2+ response amplitude and duration
TL;DR: It is reported here that the amplitude and duration of calcium signals in B lymphocytes controls differential activation of the pro–inflammatory transcriptional regulators NF-κB, c-Jun N-terminal kinase (JNK) and NFAT, revealing a mechanism by which a multifunctional second messenger such as Ca2+ can achieve specificity in signalling to the nucleus.
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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
Christopher C. Goodnow,Jeffrey Crosbie,Stephen Adelstein,Thomas B. Lavoie,Sandra J. Smith-Gill,Robert Brink,Helen Pritchard-Briscoe,John S. Wotherspoon,Robert H Loblay,Kathy Raphael,Ronald J. Trent,Antony Basten +11 more
TL;DR: Findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance.
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C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity
TL;DR: C3d is a molecular adjuvant of innate immunity that profoundly influences an acquired immune response and is found to differentiate between harmful and innocuous antigens.
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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
Carola G. Vinuesa,Matthew C. Cook,Constanza Angelucci,Vicki Athanasopoulos,Lixin Rui,Kim M. Hill,Di Yu,Heather Domaschenz,Belinda Whittle,Teresa Lambe,Ian Roberts,Richard R. Copley,John I. Bell,Richard J. Cornall,Christopher C. Goodnow +14 more
TL;DR: The mouse genome is systematically screened for autoimmune regulators to isolate a mouse strain, sanroque, with severe autoimmune disease resulting from a single recessive defect in a previously unknown mechanism for repressing antibody responses to self.