Maria Wysocka

TL;DR: In addition to inducing proliferation and clonal expansion of naive T cells, dendritic cells, by their production of IL-12, play a direct role in the development of IFN-gamma-producing cells that are important for cell-mediated immune responses.

TL;DR: In vitro depletion experiments indicated that CD4+ lymphocytes are the major source of the latter cytokine in the spleen cell populations, and in vivo depletion with anti-CD4 Abs protected the IL-10 KO mice from parasite-induced mortality.

TL;DR: In this article, the function of IL-10 synthesis during early infection with the intracellular protozoan Toxoplasma gondii was examined in mice inoculated with an avirulent parasite strain (ME-49).

TL;DR: The stimulation of macrophage-derived IL-12 plays a major role in both the induction of resistance and Th1 cell subset selection in acute T. gondii infection, but may not be required to maintain established immunity.

TL;DR: DC exhibited features that had not been seen with other antigen‐presenting cells: they produced bioactive IL‐12 upon antigen‐specific interaction with T cells without any other stimuli; in an allogeneic mixed leukocyte reaction model, neutralizing anti‐IL‐12 antibodies showed that DC‐derived IL‐ 12 was critical for optimal proliferation and IFN‐γ production by activated Th1 blasts.