G
Giorgio Trinchieri
Researcher at National Institutes of Health
Publications - 456
Citations - 83876
Giorgio Trinchieri is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Interleukin 12 & Immune system. The author has an hindex of 138, co-authored 433 publications receiving 78028 citations. Previous affiliations of Giorgio Trinchieri include National Cancer Research Institute & Schering-Plough.
Papers
More filters
Journal ArticleDOI
Interleukin-12 and the regulation of innate resistance and adaptive immunity
TL;DR: The understanding of the relative roles of IL-12 and other factors in TH1-type maturation of both CD4+ and CD8+ T cells is discussed here, including the participation in this process ofIL-23 and IL-27, two recently discovered members of the new family of heterodimeric cytokines.
Book ChapterDOI
Biology of natural killer cells.
TL;DR: The existence of NK cells has prompted a reinterpretation of both the studies of specific cytotoxicity against spontaneous human tumors and the theory of immune surveillance, at least in its most restrictive interpretation.
Journal ArticleDOI
Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity
TL;DR: IL-12 represents a functional bridge between the early nonspecific innate resistance and the subsequent antigen-specific adaptive immunity in the innate resistance/adaptive immune response to infection.
Journal ArticleDOI
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.
M Kobayashi,Lori Fitz,M Ryan,Rodney M. Hewick,Steven C. Clark,S Chan,R Loudon,F Sherman,B Perussia,Giorgio Trinchieri +9 more
TL;DR: Data strongly suggest that the same molecule mediates these three activities, although the presence of traces of contaminant peptides even in the most purified NKSF preparations does not allow us to exclude the possibility that distinct biologically active molecules have been co-purified.
Journal ArticleDOI
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
Roberto Manetti,Paola Parronchi,Maria Grazia Giudizi,Marie-Pierre Piccinni,Enrico Maggi,Giorgio Trinchieri,Sergio Romagnani +6 more
TL;DR: IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses.