Tanya Scharton-Kersten

TL;DR: The capacity of splenic DC but not MΦ to synthesize de novo high levels of IL-12 within hours of exposure to microbial products in vivo, as well as the ability of the same stimuli to induce migration of DC to the T cell areas, argues that DC function simultaneously as both antigen-presenting cells and IL- 12 producing accessory cells in the initiation of cell-mediated immunity to intracellular pathogens.

TL;DR: In vitro depletion experiments indicated that CD4+ lymphocytes are the major source of the latter cytokine in the spleen cell populations, and in vivo depletion with anti-CD4 Abs protected the IL-10 KO mice from parasite-induced mortality.

TL;DR: In this article, the function of IL-10 synthesis during early infection with the intracellular protozoan Toxoplasma gondii was examined in mice inoculated with an avirulent parasite strain (ME-49).

TL;DR: These phenotypes are largely overlapping with those observed in Bcl-3 knockout animals, but distinct from those of p50 knockouts, supporting the notion of a physiologically relevant complex of p52 homodimers and B cl-3.

TL;DR: Early resistance to Toxoplasma gondii infection was ablated by neutralization of IFN-γ or IL-12 in vivo and markedly diminished by depletion of neutrophils, demonstrating the existence of previously unappreciated NO independent mechanisms operating against the parasite during early infection.