R
Richard J. Miller
Researcher at Northwestern University
Publications - 432
Citations - 36634
Richard J. Miller is an academic researcher from Northwestern University. The author has contributed to research in topics: Voltage-dependent calcium channel & Receptor. The author has an hindex of 103, co-authored 419 publications receiving 35669 citations. Previous affiliations of Richard J. Miller include University at Buffalo & St. Francis Medical Center.
Papers
More filters
Journal ArticleDOI
Multiple calcium channels and neuronal function
TL;DR: It is shown that neurons have a number of different types of calcium channels, each with their own unique properties and pharmacology, and these calcium channels may be important in the control of different aspects of nerve activity.
Journal ArticleDOI
Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons.
Lane D. Hirning,A P Fox,Edwin W. McCleskey,Edwin W. McCleskey,Baldomero M. Olivera,Stanley A. Thayer,Richard J. Miller,Richard W. Tsien +7 more
TL;DR: N-type calcium channels play a dominant role in the depolarization-evoked release of norepinephrine, and are involved in stimulus-secretion coupling.
Journal ArticleDOI
Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine
TL;DR: Digital-imaging microfluorimetry of the oxidation of hydroethidine (HEt) to ethidium can be used to monitor superoxide (O2-) production selectively within individual rat hippocampal pyramidal neurons in culture and in brain slices.
Journal ArticleDOI
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
T. Chris Gamblin,Feng Chen,Angara Zambrano,Aida Abraha,Sarita Lagalwar,Angela L. Guillozet,Meiling Lu,Yifan Fu,Francisco García-Sierra,Nichole E. LaPointe,Richard J. Miller,Robert W. Berry,Lester I. Binder,Vincent L. Cryns +13 more
TL;DR: A novel mechanism linking amyloid deposition and neurofibrillary tangles in AD is suggested: Aβ peptides promote pathological tau filament assembly in neurons by triggering caspase cleavage of tau and generating a proteolytic product with enhanced polymerization kinetics.
Journal ArticleDOI
Immunohistochemical localization of enkephalin in rat brain and spinal cord.
TL;DR: The results of the histochemical staining show that certain structures which positively stain for enkephalin closely correspond to the distribution of opiate receptors in the brain and thus support the concept that the endogenous opiate peptides are involved in the perception of pain and analgesia.