R
Richard Jove
Researcher at City of Hope National Medical Center
Publications - 50
Citations - 9380
Richard Jove is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: STAT3 & Cancer. The author has an hindex of 30, co-authored 50 publications receiving 8850 citations. Previous affiliations of Richard Jove include Beckman Research Institute & University of South Florida.
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Journal ArticleDOI
The STATs of cancer — new molecular targets come of age
Hua Yu,Richard Jove +1 more
TL;DR: Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance, and STAT proteins — especially STAT3 and STAT5 — regulate all of these processes and are persistence activated in a surprisingly large number of human cancers.
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STATs in oncogenesis.
TL;DR: The evidence for critical roles of STATs in oncogenesis is presented and the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling is discussed.
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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity.
Marcin Kortylewski,Maciej Kujawski,Tianhong Wang,Sheng Wei,Shumin M. Zhang,Shari Pilon-Thomas,Guilian Niu,Heidi Kay,James J. Mulé,William G. Kerr,Richard Jove,Drew M. Pardoll,Hua Yu +12 more
TL;DR: It is shown that Stat3 is constitutively activated in diverse tumor-infiltrating immune cells, and ablating Stat3 in hematopoietic cells triggers an intrinsic immune-surveillance system that inhibits tumor growth and metastasis.
Journal ArticleDOI
STAT proteins: novel molecular targets for cancer drug discovery.
James Turkson,Richard Jove +1 more
TL;DR: This review evaluates constitutive Stat3 activation as a ‘cancer-causing’ factor, and proposes a number of molecular strategies for targeting Stat3 signaling for therapeutic intervention.
Journal ArticleDOI
Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors
Heehyoung Lee,Andreas Herrmann,Jie Hui Deng,Maciej Kujawski,Guilian Niu,Zhiwei Li,S.J. Forman,Richard Jove,Drew M. Pardoll,Hua Yu +9 more
TL;DR: It is shown here that maintenance of NF-kappaB activity in tumors requires Stat3, which is also frequently constitutively activated in cancer, and is central to both the transformed and nontransformed elements in tumors.