Roy Garcia

TL;DR: The evidence for critical roles of STATs in oncogenesis is presented and the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling is discussed.

TL;DR: It is shown that Src and JAK family tyrosine kinases cooperate to mediate constitutive Stat3 activation in the absence of EGF stimulation in model human breast cancer cell lines, suggesting that tyrosINE kinases transduce signals through Stat3 protein that contribute to the growth and survival of human breast cancers cells in culture and potentially in vivo.

TL;DR: Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors that were first identified as mediators of cellular responses to interferons as mentioned in this paper.

TL;DR: It is demonstrated that constitutive activation of Stat3 occurs frequently in primary prostate adenocarcinomas and is critical for the growth and survival of prostate cancer cells.

TL;DR: These findings suggest that specific Stat3 or Src inhibitors could offer clinical benefits to patients with breast cancer and suggest important roles for elevated activities of Stat3 and Src, as well as Survivin expression, in malignant progression of breast cancer.