R
Richard L. O'Brien
Researcher at University of Southern California
Publications - 27
Citations - 568
Richard L. O'Brien is an academic researcher from University of Southern California. The author has contributed to research in topics: Galactose oxidase & Lymphocyte. The author has an hindex of 15, co-authored 27 publications receiving 567 citations.
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Defective DNA repair in Fanconi's anaemia.
TL;DR: An increased susceptibility of lymphocytes from patients with FA to chromosome breakage by DNA cross linking agents is demonstrated, interpreted as an indication that FA cells are defective in some DNA repair mechanism.
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Oxidation-induced lymphocyte transformation
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Susceptibility of chromosomes from patients with Down's syndrome to 7,12‐dimethylbenz(a) anthracene‐induced aberrations in vitro
TL;DR: The susceptibility of chromosomes from seven patients with Down's syndrome to damage in vitro by 7,12‐dimethylbenz (a)anthracene (DMBA) was significantly greater than that of the chromosomes from ten healthy donors.
Journal Article
Characterization of responding cells in oxidative mitogen stimulation. II. Identification of an Ia-bearing adherent accessory cell.
TL;DR: In this article, the mitogen response to lymph node cells depeleted of adherent cells by passage over nylon wool and Sephadex columns was similar to restoration of Ia- depleted lymphocyte populations.
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Periodate-induced lymphocyte transformation. IV. Mitogenic effect of NaIO4 treated lymphocytes upon autologous lymphocytes.
TL;DR: If lymphocytes are inactivated with mitomycin C, 60Co irradiation, or ultraviolet (UV) irradiated, and treated with sodium periodate (NaIO4), they are capable of inducing transformation of autologous lymphocytes in vitro.