Richard L. Tolman

TL;DR: Novel, non-thiazolidinedione agonists for PPARγ and PPARδ that were identified by radioligand binding assays improve hyperglycemia and hypertriglyceridemia in vivo and are able to potentiate preadipocyte differentiation.

TL;DR: 2'NDG was at least 10-fold more potent than acyclovir (ACV) in inhibition of human cytomegalovirus replication and Epstein-Barr virus-induced lymphocyte transformation and was about as effective as ACV in inhibited of herpes simplex viruses 1 and 2 and varicella zoster virus.

TL;DR: It is shown that treatment of insulin resistant db/db mice with the PPARδ agonist L‐165 041, at doses that had no effect on either glucose or triglycerides, raised total plasma cholesterol concentrations, suggesting both that PPAR δ is involved in the regulation of cholesterol metabolism in db/ db mice and that PP ARδ ligands could potentially have therapeutic value.

TL;DR: Covalently modified bacterial polysaccharides and proteins, which are useful components of bacterial vaccines, can be found in this paper, and methods of preparing such poly-saccharide, proteins and conjugates and of confirming the covalency of the linkage between poly-charide and proteins.

TL;DR: In an in vivo comparison of 2′NDG with five other known antiherpetic agents including acyclovir for protection of mice against HSV-1 induced encephalitis, 2′ NDG was at least 60-fold more effective.