R
Richard Lawrence
Researcher at University of Texas Health Science Center at San Antonio
Publications - 57
Citations - 3287
Richard Lawrence is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Glutathione & Telomere. The author has an hindex of 29, co-authored 57 publications receiving 3185 citations. Previous affiliations of Richard Lawrence include University of Texas at San Antonio.
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Journal ArticleDOI
Species, Tissue and Subcellular Distribution of Non Se-Dependent Glutathione Peroxidase Activity
Richard Lawrence,Raymond F. Burk +1 more
Journal Article
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.
Elzbieta Izbicka,Richard T. Wheelhouse,Richard T. Wheelhouse,Eric Raymond,Karen Davidson,Richard Lawrence,Daekyu Sun,B. Windle,Laurence H. Hurley,D. D. Von Hoff +9 more
TL;DR: The results suggest that relevant biological effects of porphyrins can be achieved at concentrations that do not have general cytotoxic effects on cells, and support the concept that a rational, structure-based approach is possible to design novel telomere-interactive agents with application to a selective and specific anticancer therapy.
Journal ArticleDOI
Dietary n‐3 Fatty Acids Decrease Osteoclastogenesis and Loss of Bone Mass in Ovariectomized Mice
Dongxu Sun,Aparna Krishnan,Khaliquz Zaman,Richard Lawrence,Arunabh Bhattacharya,Gabriel Fernandes +5 more
TL;DR: FO decreased bone loss in ovariectomized mice because of inhibition of osteoclastogenesis and this finding supports a beneficial effect of FO on the attenuation of osteoporosis.
Journal ArticleDOI
Oxidative Stress and AP-1 Activity in Tamoxifen-Resistant Breast Tumors In Vivo
Rachel Schiff,Praveen Reddy,Markku Ahotupa,Ester Coronado-Heinsohn,Matt Grim,Susan G. Hilsenbeck,Richard Lawrence,Susan M. Deneke,Rafael E. Herrera,Gary C. Chamness,Suzanne A. W. Fuqua,Powel H. Brown,C. Kent Osborne +12 more
TL;DR: The results suggest that the conversion of breast tumors to a tamoxifen-resistant phenotype is associated with oxidative stress and the subsequent antioxidant response and with increased phosphorylated JNK and c-Jun levels and AP-1 activity, which together could contribute to tumor growth.
Journal ArticleDOI
In vitro antitumor activity of the novel marine agent, Ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients
Elzbieta Izbicka,Richard Lawrence,Eric Raymond,G. Eckhardt,G. Faircloth,Jose Jimeno,Gary M. Clark,D. D. Von Hoff +7 more
TL;DR: The data from the cloning assay indicate that the duration of exposure to ET-743 is an important factor in human tumors, and long-term exposure to the novel compound may be preferred in future clinical trials.