R
Richard Mann
Researcher at University of Pennsylvania
Publications - 15
Citations - 362
Richard Mann is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Antigen & T lymphocyte. The author has an hindex of 11, co-authored 15 publications receiving 362 citations. Previous affiliations of Richard Mann include Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Isolation and characterization of the nephritogenic antigen producing anti-tubular basement membrane disease.
M D Clayman,Antonio Martinez-Hernandez,L Michaud,Robert Alper,Richard Mann,Nicholas A. Kefalides,Eric G. Neilson +6 more
TL;DR: 3M-1 is the nephritogenic antigen producing experimental anti-TBM disease and was associated with the most lateral aspect of the TBM, which borders, and lies in the interstitium.
Journal Article
Spontaneous interstitial nephritis in kdkd mice. II. Characterization of a tubular antigen-specific, H-2K-restricted Lyt-2+ effector T cell that mediates destructive tubulointerstitial injury.
TL;DR: It is suggested that T lymphocytes reactive to a parenchymal tubular antigen are of substantial importance in the development of spontaneous interstitial nephritis in kdkd mice.
Journal Article
Murine interstitial nephritis. III. The selection of phenotypic (Lyt and L3T4) and idiotypic (RE-Id) T cell preferences by genes in Igh-1 and H-2K characterizes the cell-mediated potential for disease expression: susceptible mice provide a unique effector T cell repertoire in response to tubular antigen.
TL;DR: In this article, the effector T cell repertoire in experimental interstitial nephritis was examined in a variety of susceptible and nonsusceptible mice and it was shown that L3T4+ effector cells in disease-susceptable mice disappear soon after immunization in preference to the emergence of Lyt-2+ effectors cells.
Journal Article
Murine interstitial nephritis. IV. Long-term cultured L3T4+ T cell lines transfer delayed expression of disease as I-A-restricted inducers of the effector T cell repertoire
TL;DR: It is observed that long-term cultures of tubular antigen-reactive L3T4+ T cells from immune SJL mice are able to adoptively transfer interstitial nephritis by 12 wk after i.v. injection, indicating that the time course for optimal effector cell differentiation and potential expression is relatively short.
Journal ArticleDOI
Tubular antigen-derivatized cells induce a disease-protective, antigen-specific, and idiotype-specific suppressor T cell network restricted by I-J and Igh-V in mice with experimental interstitial nephritis.
TL;DR: These studies provide an experimental basis for further efforts to use immunoregulatory modulation in the control of autoimmune renal disease.