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Carolyn J. Kelly
Researcher at University of California, San Diego
Publications - 76
Citations - 7194
Carolyn J. Kelly is an academic researcher from University of California, San Diego. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 29, co-authored 75 publications receiving 6970 citations. Previous affiliations of Carolyn J. Kelly include Hospital of the University of Pennsylvania & University of Pennsylvania.
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Journal ArticleDOI
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
Mercedes Ricote,Andrew C. Li,Andrew C. Li,Timothy M. Willson,Carolyn J. Kelly,Christopher K. Glass +5 more
TL;DR: It is shown that PPAR-γ is markedly upregulated in activated macrophages and inhibits the expression of the inducible nitric oxide synthase, gelatinase B and scavenger receptor A genes in response to 15d-PGJ2 and synthetic PPar-γ ligands, suggesting that PPARS and locally produced prostaglandin D2 metabolites are involved in the regulation of inflammatory responses.
Journal ArticleDOI
Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
Jannet T. Huang,John S. Welch,Mercedes Ricote,Christoph J. Binder,Timothy M. Willson,Carolyn J. Kelly,Joseph L. Witztum,Colin D. Funk,Douglas Conrad,Christopher K. Glass +9 more
TL;DR: Findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands for PPAR-γ, and suggest a paradigm for the regulation of nuclear receptor function by cytokines.
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Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis
Thomas P. Haverty,Carolyn J. Kelly,William H. Hines,Peter S. Amenta,Melanie Watanabe,Robert A. Harper,Nicholas A. Kefalides,Eric G. Neilson +7 more
TL;DR: It is suggested that MCT cells provide all the necessary biological parameters for interfacing both as the target of a nephritogenic immune response, and as a potential source for new extracellular matrix which develops as a fibrogenic response to interstitial nephritis.
Journal ArticleDOI
Regulation of Cytokine Expression by Ligands of Peroxisome Proliferator Activated Receptors
Robyn Cunard,Mercedes Ricote,Dennis DiCampli,D. Clay Archer,Daniel Kahn,Christopher K. Glass,Carolyn J. Kelly,Carolyn J. Kelly +7 more
TL;DR: These findings support the roles of PPAR ligands in modulating inflammatory responses involving lymphocytes but also establish potent effects of the fibrate class of PParα ligands on IL-4 expression that are receptor independent.