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Richard T. Eastman
Researcher at National Institutes of Health
Publications - 76
Citations - 4326
Richard T. Eastman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Plasmodium falciparum & Medicine. The author has an hindex of 29, co-authored 66 publications receiving 3519 citations. Previous affiliations of Richard T. Eastman include Columbia University & University of Washington.
Papers
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Journal ArticleDOI
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
Richard T. Eastman,Jacob S. Roth,Jacob S. Roth,Kyle R. Brimacombe,Anton Simeonov,Min Shen,Samarjit Patnaik,Matthew D. Hall +7 more
TL;DR: An overview of remdesivir’s discovery, mechanism of action, and the current studies exploring its clinical effectiveness is provided.
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Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
TL;DR: The current knowledge about the mode of action of ACTs, their pharmacological properties and the proposed mechanisms of drug resistance are discussed.
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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
Sophie H. Adjalley,Geoffrey Johnston,Tao Li,Richard T. Eastman,Eric H. Ekland,Abraham G. Eappen,Adam D. Richman,B. Kim Lee Sim,Marcus C. S. Lee,Stephen L. Hoffman,David A. Fidock +10 more
TL;DR: Activity of the first-line antimalarial dihydroartemisinin and the partner drugs lumefantrine and pyronaridine against early gametocyte stages, along with moderate inhibition of mature gametocytes transmission to Anopheles mosquitoes are revealed.
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Drug-resistant malaria: molecular mechanisms and implications for public health.
TL;DR: This review attempts to summarize the unique factors presented by malarial parasites that lead to the emergence and spread of drug resistance, and gives an overview of known resistance mechanisms to currently used antimalarial drugs.
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Symptoms of Sensory Neuropathy in Adults with NIDDM in the U.S. Population
TL;DR: Symptoms of sensory neuropathy affect 30–40% of diabetic patients in the U.S. population and increases with longer duration of diabetes; hypertension and hyperglycemia predispose to symptoms of sensory Neuropathy.