S
Stephen L. Hoffman
Researcher at Naval Medical Research Center
Publications - 487
Citations - 41644
Stephen L. Hoffman is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 104, co-authored 458 publications receiving 38597 citations. Previous affiliations of Stephen L. Hoffman include Pan American Health Organization & Walter Reed Army Medical Center.
Papers
More filters
Journal ArticleDOI
Genome sequence of the human malaria parasite Plasmodium falciparum
Malcolm J. Gardner,Neil Hall,Eula Fung,Owen White,Matthew Berriman,Richard W. Hyman,Jane M. Carlton,Arnab Pain,Karen E. Nelson,Sharen Bowman,Ian T. Paulsen,Keith D. James,Jonathan A. Eisen,Kim Rutherford,Steven L. Salzberg,Alister Craig,Sue Kyes,Man Suen Chan,Vishvanath Nene,Shamira J. Shallom,Bernard B. Suh,Jeremy Peterson,Samuel V. Angiuoli,Mihaela Pertea,Jonathan E. Allen,Jeremy D. Selengut,Daniel H. Haft,Michael W. Mather,Akhil B. Vaidya,David M. A. Martin,Alan H. Fairlamb,Martin Fraunholz,David S. Roos,Stuart A. Ralph,Geoffrey I. McFadden,Leda M. Cummings,G. Mani Subramanian,Christopher J. Mungall,J. Craig Venter,Daniel J. Carucci,Stephen L. Hoffman,Chris I. Newbold,Ronald W. Davis,Claire M. Fraser,Bart Barrell +44 more
TL;DR: The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
Journal ArticleDOI
The Genome Sequence of the Malaria Mosquito Anopheles gambiae
Robert A. Holt,G. Mani Subramanian,Aaron L. Halpern,Granger G. Sutton,Rosane Charlab,Deborah R. Nusskern,Patrick Wincker,Andrew G. Clark,José M. C. Ribeiro,Ron Wides,Steven L. Salzberg,Brendan J. Loftus,Mark Yandell,William H. Majoros,William H. Majoros,Douglas B. Rusch,Zhongwu Lai,Cheryl L. Kraft,Josep F. Abril,Véronique Anthouard,Peter Arensburger,Peter W. Atkinson,Holly Baden,Véronique de Berardinis,Danita Baldwin,Vladimir Benes,Jim Biedler,Claudia Blass,Randall Bolanos,Didier Boscus,Mary Barnstead,Shuang Cai,Kabir Chatuverdi,George K. Christophides,Mathew A. Chrystal,Michele Clamp,Anibal Cravchik,Val Curwen,Ali N Dana,Arthur L. Delcher,Ian M. Dew,Cheryl A. Evans,Michael Flanigan,Anne Grundschober-Freimoser,Lisa Friedli,Zhiping Gu,Ping Guan,Roderic Guigó,Maureen E. Hillenmeyer,Susanne L. Hladun,James R. Hogan,Young S. Hong,Jeffrey Hoover,Olivier Jaillon,Zhaoxi Ke,Zhaoxi Ke,Chinnappa D. Kodira,Kokoza Eb,Anastasios C. Koutsos,Ivica Letunic,Alex Levitsky,Yong Liang,Jhy-Jhu Lin,Jhy-Jhu Lin,Neil F. Lobo,John Lopez,Joel A. Malek,Tina C. McIntosh,Stephan Meister,Jason R. Miller,Clark M. Mobarry,Emmanuel Mongin,Sean D. Murphy,David A. O'Brochta,Cynthia Pfannkoch,Rong Qi,Megan A. Regier,Karin A. Remington,Hongguang Shao,Maria V. Sharakhova,Cynthia Sitter,Jyoti Shetty,Thomas J. Smith,Renee Strong,Jingtao Sun,Dana Thomasova,Lucas Q. Ton,Pantelis Topalis,Zhijian Tu,Maria F. Unger,Brian P. Walenz,Aihui Wang,Jian Wang,Mei Wang,X. Wang,Kerry J. Woodford,Jennifer R. Wortman,Jennifer R. Wortman,Martin Wu,Alison Yao,Evgeny M. Zdobnov,Hongyu Zhang,Qi Zhao,Shaying Zhao,Shiaoping C. Zhu,Igor F. Zhimulev,Mario Coluzzi,Alessandra della Torre,Charles Roth,Christos Louis,Francis Kalush,Richard J. Mural,Eugene W. Myers,Mark Raymond Adams,Hamilton O. Smith,Samuel Broder,Malcolm J. Gardner,Claire M. Fraser,Ewan Birney,Peer Bork,Paul T. Brey,J. Craig Venter,J. Craig Venter,Jean Weissenbach,Fotis C. Kafatos,Frank H. Collins,Stephen L. Hoffman +126 more
TL;DR: Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted.
Journal ArticleDOI
Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
Ruobing Wang,Denise L. Doolan,Thong P. Le,Richard C. Hedstrom,Kevin M. Coonan,Yupin Charoenvit,Trevor R. Jones,Peter Hobart,Michal Margalith,Jennifer Ng,Walter R. Weiss,Martha Sedegah,Charles de Taisne,Jon Norman,Stephen L. Hoffman +14 more
TL;DR: This first demonstration in healthy naïve humans of the induction of CD8+ C TLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology.
Journal ArticleDOI
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Jane M. Carlton,Jane M. Carlton,John H. Adams,Joana C. Silva,Shelby L. Bidwell,Hernan Lorenzi,Elisabet Caler,Jonathan Crabtree,Jonathan Crabtree,Samuel V. Angiuoli,Emilio F. Merino,Paolo Amedeo,Qin Cheng,Richard M.R. Coulson,Brendan S. Crabb,Hernando A. del Portillo,Kobby Essien,T. Feldblyum,Carmen Fernandez-Becerra,Paul R. Gilson,Amy H. Gueye,Xiang Guo,Simon Kang’a,Taco W. A. Kooij,Michael Korsinczky,Michael Korsinczky,Esmeralda V. S. Meyer,Vish Nene,Ian T. Paulsen,Owen White,Stuart A. Ralph,Qinghu Ren,Tobias Sargeant,Steven L. Salzberg,Christian J. Stoeckert,Steven A. Sullivan,Marcio Massao Yamamoto,Stephen L. Hoffman,Jennifer R. Wortman,Malcolm J. Gardner,Mary R. Galinski,John W. Barnwell,Claire M. Fraser-Liggett +42 more
TL;DR: The synteny and isochore structure of P. vivax chromosomes are described, and it is shown that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously.
Journal ArticleDOI
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
Jane M. Carlton,Samuel V. Angiuoli,Bernard B. Suh,Taco W. A. Kooij,Mihaela Pertea,Joana C. Silva,Maria D. Ermolaeva,Jonathan E. Allen,Jeremy D. Selengut,Hean L. Koo,Jeremy Peterson,Mihai Pop,Daniel S. Kosack,Martin Shumway,Shelby L. Bidwell,Shamira J. Shallom,Susan Van Aken,Steven B. Riedmuller,Tamara Feldblyum,Jennifer Cho,John Quackenbush,Martha Sedegah,Azadeh Shoaibi,Leda M. Cummings,Laurence Florens,John R. Yates,J. Dale Raine,Robert E. Sinden,Michael Harris,Deirdre A. Cunningham,Peter R. Preiser,Lawrence W. Bergman,Akhil B. Vaidya,Leo H.M. van Lin,Chris J. Janse,Andrew P. Waters,Hamilton O. Smith,Owen White,Steven L. Salzberg,J. Craig Venter,Claire M. Fraser,Stephen L. Hoffman,Malcolm J. Gardner,Daniel J. Carucci +43 more
TL;DR: This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.