R
Richard T. Eastman
Researcher at National Institutes of Health
Publications - 76
Citations - 4326
Richard T. Eastman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Plasmodium falciparum & Medicine. The author has an hindex of 29, co-authored 66 publications receiving 3519 citations. Previous affiliations of Richard T. Eastman include Columbia University & University of Washington.
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Journal ArticleDOI
Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy: incidence and time course.
Nilo A. Avila,Thomas H. Shawker,Paris Roach,Mary H. Bradford,Monica C. Skarulis,Richard T. Eastman +5 more
TL;DR: The effects of octreotide and ursodiol on the gallbladders of patients with acromegaly are studied.
Journal ArticleDOI
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Claire Le Manach,Jean Dam,John G Woodland,Gurminder Kaur,Lutete Peguy Khonde,Christel Brunschwig,Mathew Njoroge,Kathryn J. Wicht,André Horatscheck,Tanya Paquet,Grant A. Boyle,Liezl Gibhard,Dale Taylor,Nina Lawrence,Tomas Yeo,Sachel Mok,Richard T. Eastman,Dorjbal Dorjsuren,Daniel C. Talley,Hui Guo,Anton Simeonov,Janette Reader,Mariëtte van der Watt,Erica Erlank,Erica Erlank,Nelius Venter,Nelius Venter,Jacek W. Zawada,Jacek W. Zawada,Ayesha Aswat,Ayesha Aswat,Luisa Nardini,Luisa Nardini,Theresa L. Coetzer,Sonja B Lauterbach,Belinda C. Bezuidenhout,Anjo Theron,Dalu Mancama,Lizette L. Koekemoer,Lizette L. Koekemoer,Lyn-Marie Birkholtz,Sergio Wittlin,Sergio Wittlin,Michael J. Delves,Michael J. Delves,Sabine Ottilie,Elizabeth A. Winzeler,Thomas W. von Geldern,Dennis A. Smith,David A. Fidock,Leslie J. Street,Gregory S. Basarab,James Duffy,Kelly Chibale,Kelly Chibale +54 more
TL;DR: A novel diazaspiro[34] octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign.
Journal ArticleDOI
Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Khalida Shamim,Miao Xu,Xin Hu,Emily M. Lee,Xiao Lu,Ruili Huang,Pranav Shah,Xin Xu,Catherine Z. Chen,Min Shen,Hui Guo,Lu Chen,Zina Itkin,Richard T. Eastman,Paul Shinn,Carleen Klumpp-Thomas,Sam Michael,Anton Simeonov,Donald C. Lo,Guo Li Ming,Hongjun Song,Hengli Tang,Wei Zheng,Wenwei Huang +23 more
TL;DR: In this paper, the authors conducted SAR studies focusing on the anilide and salicylic acid regions of niclosamide to improve physicochemical properties such as microsomal metabolic stability, permeability and solubility.
Journal ArticleDOI
mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening
Lu Chen,Kelli M. Wilson,Ian S. Goldlust,Bryan T. Mott,Richard T. Eastman,Mindy I. Davis,Xiaohu Zhang,Crystal McKnight,Carleen Klumpp-Thomas,Paul Shinn,John K. Simmons,Michael V. Gormally,Sam Michael,Craig J. Thomas,Marc Ferrer,Rajarshi Guha +15 more
TL;DR: The data indicates that mQC is a reliable QC filter that can be used to identify problematic drug combinations matrices and prevent further analysis on erroneously active combinations as well as for troubleshooting failed screens.
Journal ArticleDOI
A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike
Ying Fu,Juliana da Fonseca Rezende e Mello,Bryan D. Fleming,Alex Renn,Catherine Chen,Xin Hu,Miao Xu,Kirill Gorshkov,Quinlin M. Hanson,Wei Zheng,Emily M. Lee,Lalith Perera,R. Petrovich,Manisha Pradhan,Richard T. Eastman,Zina Itkin,T. Stanley,Allen L. Hsu,Venkata P. Dandey,William K. Gillette,Troy Taylor,Nitya Ramakrishnan,Shelley C. Perkins,Dominic Esposito,Eunkeu Oh,Kimihiro Susumu,Mason A. Wolak,Marc Ferrer,Matthew Hall,Mario J. Borgnia,Anton Simeonov +30 more
TL;DR: A rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody constructs with sub-nanomolar affinities and nanomolar potencies is reported.