R
Rika Maruyama
Researcher at University of Alberta
Publications - 47
Citations - 1477
Rika Maruyama is an academic researcher from University of Alberta. The author has contributed to research in topics: Exon skipping & Duchenne muscular dystrophy. The author has an hindex of 16, co-authored 42 publications receiving 1110 citations. Previous affiliations of Rika Maruyama include Johns Hopkins University School of Medicine & Rutgers University.
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Eteplirsen in the treatment of Duchenne muscular dystrophy
TL;DR: Eteplirsen is a drug that acts to promote dystrophin production by restoring the translational reading frame of DMD through specific skipping of exon 51 in defective gene variants, which is applicable for approximately 14% of patients with DMD mutations.
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Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy
Yusuke Echigoya,Akinori Nakamura,Tetsuya Nagata,Nobuyuki Urasawa,Kenji Rowel Q. Lim,Nhu Trieu,Dharminder Panesar,Mutsuki Kuraoka,Hong M. Moulton,Takashi Saito,Yoshitsugu Aoki,Patrick L. Iversen,Peter Sazani,Ryszard Kole,Rika Maruyama,T. Partridge,T. Partridge,Shin'ichi Takeda,Toshifumi Yokota,Toshifumi Yokota +19 more
TL;DR: It is shown that systemic multiexon skipping using a cocktail of peptide-conjugated morpholinos (PPMOs) rescued dystrophin expression in the myocardium and cardiac Purkinje fibers in a dystrophic dog model and leads to the improvement/prevention of cardiac conduction abnormalities in the Dystrophic heart.
Journal ArticleDOI
Skipping Multiple Exons to Treat DMD-Promises and Challenges.
TL;DR: Significant changes are needed in the drug approval process to promote the cocktail AO approach, because both exons 6 and 8 need to be skipped to restore the reading frame in dystrophic dogs and the current drug approval system is not designed to evaluate such circumstances.
Journal ArticleDOI
EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans.
Rika Maruyama,Nathalie V. Velarde,Richard Klancer,Scott M. Gordon,Pavan Kadandale,Jean M. Parry,Julie S. Hang,Jacob Rubin,Allison Stewart-Michaelis,Peter J. Schweinsberg,Barth D. Grant,Fabio Piano,Asako Sugimoto,Andrew Singson +13 more
TL;DR: Caenorhabditis elegans EGG-3 plays a central role in egg activation by influencing polarized F-actin dynamics and the localization or activity of molecules that are directly involved in executing the egg-to-embryo transition.
Journal ArticleDOI
EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans.
Jean M. Parry,Nathalie V. Velarde,Ariel J Lefkovith,Matthew H. Zegarek,Julie S. Hang,Jonathan Ohm,Richard Klancer,Rika Maruyama,Marina Druzhinina,Barth D. Grant,Fabio Piano,Andrew Singson +11 more
TL;DR: EGG-4 and EGG-5 are not only required for critical events of the oocyte-to-embryo transition but also link the dynamics of the regulatory machinery with the advancing cell cycle.